Results 91 to 100 of about 120,334 (323)

Functional Proteins Involved in Regulation of Intracellular Ca2+ for Drug Development: Role of Calcium/Calmodulin-Dependent Protein Kinases in Ischemic Neuronal Death

Journal of Pharmacological Sciences, 2005
Excessive elevation of intracellular calcium level seems to be a trigger of ischemic neuronal injury. Calcium/calmodulin (CaM)-dependent protein kinase kinase (CaM-KK) is an upstream kinase for CaM kinase IV (CaM-KIV) that was reported to prevent ...
Shigetoshi Yano, Motohiro Morioka, Jun-ichi Kuratsu, Kohji Fukunaga   +3 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

CD44ICD promotes breast cancer stemness via PFKFB4-mediated glucose metabolism. [PDF]

, 2018
CD44 is a single-pass cell surface glycoprotein that is distinguished as the first molecule used to identify cancer stem cells in solid tumors based on its expression.
Gao, Ruifang, Li, Dan, Li, Jun, Li, Xiru, Liu, Chen, Luo, Na, Qiao, Huan, Shen, Wenzhi, Stupack, Dwayne G, Wang, Juan, Xun, Jing, Zhou, Wei   +11 more
core  

Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C. [PDF]

, 2013
VLGR1 (very large G protein-coupled receptor 1), also known as MASS1 (monogenic audiogenic seizure susceptible 1), is an orphan G protein-coupled receptor that contains a large extracellular N terminus with 35 calcium-binding domains.
Fu, Ying-Hui, Lin, Shu-Ting, Ptácek, Louis J, Shin, Daesung   +3 more
core   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Local Translation and Retrograde Axonal Transport of CREB Regulates IL-6-Induced Nociceptive Plasticity

Molecular Pain, 2014
Transcriptional regulation of genes by cyclic AMP response element binding protein (CREB) is essential for the maintenance of long-term memory. Moreover, retrograde axonal trafficking of CREB in response to nerve growth factor (NGF) is critical for the ...
Ohannes K Melemedjian, Dipti V Tillu, Jamie K Moy, Marina N Asiedu, Edward K Mandell, Sourav Ghosh, Gregory Dussor, Theodore J Price   +7 more
doaj   +1 more source

ATP Released by Injured Neurons Activates Schwann Cells [PDF]

, 2016
Injured nerve terminals of neuromuscular junctions (NMJs) can regenerate. This remarkable and complex response is governed by molecular signals that are exchanged among the cellular components of this synapse: motor axon nerve terminal (MAT ...
Cesare eMontecucco, Cesare eMontecucco, Elisa eDuregotti, Elisanna eBergamin, Kees eJalink, Michela eRigoni, Michele eScorzeto, Samuele eNegro, Umberto eRodella   +8 more
core   +2 more sources

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Changes in CREB activation in the prefrontal cortex and hippocampus blunt ethanol-induced behavioral sensitization in adolescent mice

Frontiers in Integrative Neuroscience, 2013
Drug dependence is a major health problem in adults and has been recognized as a significant problem in adolescents. We previously demonstrated that repeated treatment with a behaviorally sensitizing dose of ethanol in adult mice induced tolerance or no ...
Sabrina Lucio Soares-Simi, Daniel Mazzeo Pastrello, Zulma Silva Ferreira, Mauricio eYonamine, Tania eMarcourakis, Cristoforo eScavone, Rosana eCamarini   +6 more
doaj   +1 more source

Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling. [PDF]

, 2015
Although PI3Kγ has been extensively investigated in inflammatory and cardiovascular diseases, the exploration of its functions in the brain is just at dawning.
Alessandra Ghigo, Angelo Maffei, Daniela Carnevale, Emilio Hirsch, Fabio Pallante, Franklin KBJ, Giuseppe Lembo, Ivana D'Andrea, Roberta Iacobucci, Stefania Fardella, Valentina Fardella   +10 more
core   +1 more source