Results 161 to 170 of about 73,335 (261)

Disruption of primary ciliary prostaglandin E₂ signaling by transforming growth factor-β1 impairs endometrial receptivity. [PDF]

J Biomed Sci
Hou HT, Li WN, Lin TC, Lin CW, Pan PH, Lee CJ, Chen YC, Chen PF, Wang CY, Wu MH, Tsai SJ.   +10 more
europepmc   +1 more source

Insomnia‐Driven Hippocampal Atrophy: Evidence From Bidirectional Mendelian Randomization

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Observational studies link insomnia to hippocampal atrophy, yet causal inference remains limited by confounding and reverse causality. While Mendelian randomization (MR) studies have explored sleep‐brain associations, bidirectional causality between insomnia and hippocampal subfield volumes remains unaddressed.
Dandan Han, Xiang Li, Shaohua Zhao, Jiayin Liu, Xiaojiang Wang, Yu Jiang, Junrong Ding, Baojing Wang, Erfeng Cui, Ding Huang   +9 more
wiley   +1 more source

Effects of Short-Term Exposure to Polystyrene Nanoplastics on the Nervous System: Calcium Homeostasis, BDNF and Synaptic Plasticity. [PDF]

Toxics
Zhao Y, Yan L, Wei Y, Ma J, Chen J, Liu X, Mi Y, Wang B, Zhang L, Tian L, Lin B.   +10 more
europepmc   +1 more source

Global Burden of Lead Exposure: Integrating Epidemiology, Molecular Mechanisms, and Mitigation Approaches

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Lead is a nonessential, toxic heavy metal that causes widespread environmental contamination, affecting humans, animals, plants, and ecosystems. Globally, an estimated 800 million children have blood lead levels (BLLs) above 5 µg/dL.
Gudisa Bereda
wiley   +1 more source

Trazodone modulates behavioral alterations in scopolamine-induced cognitive deficit by targeting brain-derived neurotropic factor and cAMP response element-binding protein signaling. [PDF]

Front Cell Neurosci
Dhaka P, Pinky, Neha, Khan MA, Rabbani SA, El-Tanani M, Parvez S.   +6 more
europepmc   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, Volume 12, Issue 1, Page 96-122, Spring 2026.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Beyond Neurotrophins: A Proposed Neurotrophic-Epigenetic Axis Mediated by Non-Coding RNA Networks for <i>Hericium erinaceus</i> Bioactives-A Hypothesis-Driven Review. [PDF]

Int J Mol Sci
Cipriano GL, Raffaele I, Floramo A, Argento V, Donato DS, Malatino C, Silvestro S, Schepici G, Astorino MF, Calabrò M, Anchesi I.   +10 more
europepmc   +1 more source

Move beyond free radical theory of aging

iMetaOmics, Volume 3, Issue 1, March 2026.
Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley   +1 more source

Schisantherin A: Remodeling Gut Microbiota to Activate the Gut–Immune–Neural–Adipose Axis for Thermogenesis

iNew Medicine, Volume 2, Issue 1, March 2026.
ABSTRACT The global obesity epidemic necessitates safe and effective strategies to enhance energy expenditure. Schisantherin A (Sin A), a lignan derived from Schisandra chinensis, has demonstrated metabolic benefits, yet its systemic mechanism remains unclear.
Ling Yin
wiley   +1 more source

ucOCN Promotes Testosterone Synthesis via the PKA-MAPK/ERK-CREB Signaling Pathway in Porcine Leydig Cells. [PDF]

Cells
Yang G, Liu H, Yin Z, Zhao L, Chen Y, Li Y, Cheng L, Ma J, Yu J, Zhang Y, Li X, Li R.   +11 more
europepmc   +1 more source