Results 51 to 60 of about 139,153 (288)

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour [PDF]

, 2016
The five-subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in
Insall, Robert H., Machesky, Laura M., Spence, Heather J., Strathdee, Douglas, Tyrrell, Benjamin J., Woodham, Emma F.   +5 more
core   +1 more source

Early induction of CREB activation and CREB-regulating signalling by antidepressants

The International Journal of Neuropsychopharmacology, 2009
Converging evidence points to adaptive changes in neuroplasticity and gene expression as mediators of therapeutic action of antidepressants. Activation of cAMP response-element binding protein (CREB) and CREB-regulating signalling are considered main effectors in these mechanisms.
D. Tardito, L. Musazzi, E. Tiraboschi, A. Mallei, G. Racagni, M. Popoli   +5 more
openaire   +3 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

CD44ICD promotes breast cancer stemness via PFKFB4-mediated glucose metabolism. [PDF]

, 2018
CD44 is a single-pass cell surface glycoprotein that is distinguished as the first molecule used to identify cancer stem cells in solid tumors based on its expression.
Gao, Ruifang, Li, Dan, Li, Jun, Li, Xiru, Liu, Chen, Luo, Na, Qiao, Huan, Shen, Wenzhi, Stupack, Dwayne G, Wang, Juan, Xun, Jing, Zhou, Wei   +11 more
core  

Nuclear expression of PG-21, SRC-1, and pCREB in regions of the lumbosacral spinal cord involved in pelvic innervation in young adult and aged rats [PDF]

, 2012
In rats, ageing results in dysfunctional patterns of micturition and diminished sexual reflexes that may reflect degenerative changes within spinal circuitry.
Amandusson, Anderson, Balazs, Berkley, Blanchet, Blanco, Blok, Breedlove, Breedlove, Burke, Chambers, Chambers, Collins, Dail, Davidson, De Cesare, Dering, Dering, Eika, Ernfors, Fargo, Ferrini, Finkbeiner, Frankel, Fraser, Ghanadian, Giuliano, Goldstein, Goldstein, Gonzalez, Gray, Gréco, Hancock, Hodges, Holmes, Hsu, Johnson, Jordan, Jordan, Jordan, Kepper, Kurz, Labombarda, Leo, Leslie, Lubischer, Marson, Marson, Marson, Marson, Marson, Matsumoto, Matsumoto, Matsumoto, Matsumoto, Matsumoto, Matsumoto, Mattson, Mayr, McKenna, McKenna, McManus, Meisel, Monks, Monks, Montminy, Nadelhaft, Nadelhaft, Nadelhaft, Nicolopoulos-Stournaras, Nordeen, O'Bryant, Osborne, Papka, Papka, Papka, Papka, Papka, Purinton, Ranson, Ranson, Ranson, Ranson, Ranson, Ranson, Reichardt, Santer, Schrøder, Sengelaub, Shibata, Smith, Smith, Tan, Tang, Tobin, Ulfhake, VanderHorst, Vera, Watkins, Watson, Williams, Wu, Wu, Yaici, Yamamoto, Yan, Yang, Yang, Yaïci   +108 more
core   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

The Transcription Factor Creb is Involved in Sorafenib-Inhibited Renal Cancer Cell Proliferation, Migration and Invasion

Acta Pharmaceutica, 2018
Our previous reports showed that the cyclic-AMP-response element-binding protein (CREB) served as a proto-oncogene in the process of tumorigenesis and mediated the growth and metastatic activity of renal cancer cells.
Huang Shuaishuai, Cui Pinger, Lin Shuangxia, Yao Xuping, Wang Xue, Ren Yu, Weng Guobin   +6 more
doaj   +1 more source

TRPV1 agonist, capsaicin, induces axon outgrowth after injury via Ca2+/PKA signaling [PDF]

, 2018
Preconditioning nerve injuries activate a pro-regenerative program that enhances axon regeneration for most classes of sensory neurons. However, nociceptive sensory neurons and central nervous system neurons regenerate poorly.
DiAntonio, Aaron, Frey, Erin, Karney-Grobe, Scott, Krolak, Trevor, Milbrandt, Jeff   +4 more
core   +2 more sources

Recruitment of CREB Binding Protein Is Sufficient for CREB-Mediated Gene Activation [PDF]

Molecular and Cellular Biology, 2000
Phosphorylation of the transcription factor CREB leads to the recruitment of the coactivator, CREB binding protein (CBP). Recent studies have suggested that CBP recruitment is not sufficient for CREB function, however. We have identified a conserved protein-protein interaction motif within the CBP-binding domains of CREB and another transcription ...
J R, Cardinaux, J C, Notis, Q, Zhang, N, Vo, J C, Craig, D M, Fass, R G, Brennan, R H, Goodman   +7 more
openaire   +2 more sources