Results 31 to 40 of about 87,086 (298)

Recruitment of CREB Binding Protein Is Sufficient for CREB-Mediated Gene Activation [PDF]

Molecular and Cellular Biology, 2000
Phosphorylation of the transcription factor CREB leads to the recruitment of the coactivator, CREB binding protein (CBP). Recent studies have suggested that CBP recruitment is not sufficient for CREB function, however. We have identified a conserved protein-protein interaction motif within the CBP-binding domains of CREB and another transcription ...
J R, Cardinaux, J C, Notis, Q, Zhang, N, Vo, J C, Craig, D M, Fass, R G, Brennan, R H, Goodman   +7 more
openaire   +2 more sources

CREB-B modulates phase-related locomotor activity under NPF2 regulation.

, 2019
(A) and (B) Effects on p-CREB-B level after injection NPF1a or NPF2 peptide in G-phase locusts. (C) and (D) Effects on p-CREB-B level after transcript knockdown of NPF1a or NPF2 in S-phase locusts (n = 4 replicates, 8–12 locusts/replicate, *P P NPF2 and ...
Xianhui Wang (153325), Le Kang (78946), Li Hou (460220), Beibei Li (280092), Ding Ding (346784)   +4 more
core   +1 more source

α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 Ameliorates Cognitive Impairment Induced by Chronic Intermittent Hypoxia

Nature and Science of Sleep, 2021
Hui Shen, Yanling Meng, Dan Liu, Zheng Qin, Hong Huang, Lei Pan, Wei Wang, Jian Kang Institute of Respiratory Disease, The First Hospital of China Medical University, Shenyang, People’s Republic of ChinaCorrespondence: Wei WangInstitute of ...
Shen H, Meng Y, Liu D, Qin Z, Huang H, Pan L, Wang W, Kang J   +7 more
doaj  

CREB-B displays dynamic phosphorylation levels and regulates locomotor activity during locust phase transition.

, 2019
(A) Total distance moved (TDM) and (B) total duration of movement (TDMV) in G-phase locusts after transcript knockdown of CREB-B (n ≥ 17 locusts, **P P CREB-B (n ≥ 15 locusts, ***P CREB-B transcription levels in G-phase and S-phase locust brains.
Xianhui Wang (153325), Le Kang (78946), Li Hou (460220), Beibei Li (280092), Ding Ding (346784)   +4 more
core   +1 more source

MLL and CREB Bind Cooperatively to the Nuclear Coactivator CREB-Binding Protein [PDF]

Molecular and Cellular Biology, 2001
A fragment of the mixed-lineage leukemia (MLL) gene (Mll, HRX, ALL-1) was identified in a yeast genetic screen designed to isolate proteins that interact with the CREB-CREB-binding protein (CBP) complex. When tested for binding to CREB or CBP individually, this MLL fragment interacted directly with CBP, but not with CREB.
P, Ernst, J, Wang, M, Huang, R H, Goodman, S J, Korsmeyer   +4 more
openaire   +2 more sources

CREB-B interacts with NOS promoter region and regulates NOS transcription in the locust brain.

, 2019
Effects of RNAi-mediated silencing of CREB encoding genes on NOS transcription (A) in the G-phase locusts (n = 4 replicates, 6–8 locusts/replicate, Student’s t-test, *P P NOS promoter.
Xianhui Wang (153325), Le Kang (78946), Li Hou (460220), Beibei Li (280092), Ding Ding (346784)   +4 more
core   +1 more source

DHA (omega-3 fatty acid) increases the action of brain-derived neurotrophic factor (BDNF)

Oilseeds and fats, crops and lipids
Neurons have high energy needs, requiring a continuous supply of glucose from the blood. Tight regulation of glucose metabolism in response to stimuli is essential for brain physiology.
Majou Didier, Dermenghem Anne-Lise
doaj   +1 more source

PABPN1 functions as a downstream gene of CREB to inhibit the proliferation of preadipocytes [PDF]

Animal Bioscience
Objective This study was conducted to reveal the role of nuclear poly(A) binding protein 1 (PABPN1) in the proliferation of preadipocytes, and to reveal the relationship between PABPN1 and cAMP response element (CRE)-binding protein (CREB) in the ...
Xiao-Han Zhang, Jia-Xin Li, Xiao-Xu Wu, Qian Zhang, Ming Tian, Si-Qi Yang, Di Liu, Xiu-Qin Yang   +7 more
doaj   +1 more source

Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2 [PDF]

Proceedings of the National Academy of Sciences, 2012
Basic leucine zipper (bZip) transcription factors regulate cellular gene expression in response to a variety of extracellular signals and nutrient cues. Although the bZip domain is widely known to play significant roles in DNA binding and dimerization, recent studies point to an additional role for this motif in the recruitment of the transcriptional ...
Qianyi, Luo, Kristin, Viste, Janny Concha, Urday-Zaa, Ganesan, Senthil Kumar, Wen-Wei, Tsai, Afsaneh, Talai, Kelly E, Mayo, Marc, Montminy, Ishwar, Radhakrishnan   +8 more
openaire   +2 more sources

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source