Results 21 to 30 of about 87,086 (298)

Hemisynthesis and Biological Evaluation of Cinnamylated, Benzylated, and Prenylated Dihydrochalcones from a Common Bio-Sourced Precursor

open access: yesAntibiotics, 2021
Several families of naturally occurring C-alkylated dihydrochalcones display a broad range of biological activities, including antimicrobial and cytotoxic properties, depending on their alkylation sidechain. The catalytic Friedel–Crafts alkylation of the
Anne Ardaillou   +4 more
doaj   +1 more source

Preprint: Histone acetyltransferase activity of CREB-binding protein is essential for synaptic plasticity in Lymnaea

open access: yes, 2021
In eukaryotes, CREB-binding protein (CBP), a coactivator of CREB, functions both as a platform for recruiting other components of the transcriptional machinery and as a histone acetyltransferase (HAT) that alters chromatin structure. We previously showed
Kemenes, I.   +12 more
core   +1 more source

Effect of crocin carotenoid on BDNF and CREB gene expression in brain ventral tegmental area of morphine treated rats

open access: yesAsian Pacific Journal of Tropical Biomedicine, 2018
Objective: To investigate the effect of crocin carotenoid on BNDF and CREB gene expression in the brain ventral tegmental area (VTA) and the serum level of BDNF in morphine-treated rats compared to control.
Marzieh Rezai   +5 more
doaj   +1 more source

Antidepressant effects of aqueous extract of saffron and its effects on CREB, P-CREB, BDNF, and VGF proteins in rat cerebellum

open access: yesJournal of Pharmacopuncture, 2018
Objective:The role of BDNF (brain-derived neurotrophic factor), CREB (cAMP response element binding) and VGF neuropeptide has been proved in antidepressant activity of long term saffron administration in the rat hippocampus.
Najmeh Asrari   +6 more
doaj   +1 more source

Selectivity of direct plasma treatment and plasma-conditioned media in bone cancer cell lines

open access: yesScientific Reports, 2021
Atmospheric pressure plasma jets have been shown to impact several cancer cell lines, both in vitro and in vivo. These effects are based on the biochemistry of the reactive oxygen and nitrogen species generated by plasmas in physiological liquids ...
Inès Hamouda   +4 more
doaj   +1 more source

Studying the Effect of Lactobacillus fermentum on Arc and CREB Genes Expression of Involved in The Memory of Alzheimer\'s Rats [PDF]

open access: yesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2023
Introduction: Alzheimer's disease is a common progressive neurogenerative disease that leads to dementia and destruction of brain cells, especially in areas related to learning and memory such as the hippocampus.
Elnaz Mogaddam   +3 more
doaj  

Supplementary Material for: Novel Phenylethanoid Glycosides Improve Hippocampal Synaptic Plasticity via the cAMP-CREB-BDNF Pathway in APP/PS1 Transgenic Mice

open access: yes, 2023
Introduction: Alzheimer’s disease (AD) is a major public health concern worldwide, but there are still no drugs available that treat it effectively. Previous studies have shown that phenylethanoid glycosides (PhGs) have pharmacological effects, which ...
Susan M. Keenan (755174)   +7 more
core   +1 more source

Acetylation of cAMP-responsive Element-binding Protein (CREB) by CREB-binding Protein Enhances CREB-dependent Transcription [PDF]

open access: yesJournal of Biological Chemistry, 2003
The coactivator function of cAMP-responsive element-binding protein (CREB)-binding protein (CBP) is partly caused by its histone acetyltransferase activity. However, it has become increasingly clear that CBP acetylates both histones and non-histone proteins, many of which are transcription factors. Here we investigate the role of CBP acetylase activity
Qing, Lu   +4 more
openaire   +2 more sources

Learning and nicotine interact to increase CREB phosphorylation at the jnk1 promoter in the hippocampus

open access: yes, 2012
Nicotine is known to enhance long-term hippocampus dependent learning and memory in both rodents and humans via its activity at nicotinic acetylcholinergic receptors (nAChRs).
Rachel L Poole   +14 more
core   +1 more source

Ending Restenosis: Inhibition of Vascular Smooth Muscle Cell Proliferation by cAMP

open access: yesCells, 2019
Increased vascular smooth muscle cell (VSMC) proliferation contributes towards restenosis after angioplasty, vein graft intimal thickening and atherogenesis.
Sarah A. Smith   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy