Results 111 to 120 of about 16,122 (303)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

INFLUENCE OF CREEP‐FATIGUE INTERACTION ON HIGH TEMPERATURE FATIGUE CRACK GROWTH BEHAVIOR of Ti‐1100

, 1994
— A series of crack growth experiments has been preformed on the near alpha titanium alloy, Ti‐1100, to determine the mechanism of the creep‐fatigue interaction.
H. Ghonem, A. H. Rosenberger, Rosenberger, A. H., Ghonem, H.   +3 more
core   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

An Analysis on Creep-Fatigue Failure of Main Steam Pipe of 12CrMoV Steel

Teshugang, 2009
Failure crack character of φ273 mm x 22 mm main steam pipe of 12CrMoV steel (0. 12C, 0. 45Cr, 0. 31 Mo, 0. 22V) serviced for 30 000 h under the condition of creep-fatigue interaction serviced al power station has been studied and analyzed. Results showed
王海燕, 高雪云, 刘宗昌, 王玉峰   +3 more
doaj  

Creep-Fatigue Interactions of Gas Turbine Materials

Defence Science Journal, 1988
The military aircraft gas turbine engines are often required to undergo a complex set of.operating conditions where the load varies considerably with respect to time. The temperature range for performing such requirements also increases as the thrust increases.The modern design of gas turbine demands very high thrust-to-weight ratio.
openaire   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Recommendation for creep and creep-fatigue assessment for P91 components

, 2015
This report is based on the results and experience gained in assessing both public domain and MATTER data, some previously reported in the MATTER deliverable D4.5: "Creep-fatigue interaction rules for P91" and some assessed here.
Pohja, Rami, Lee, Hyeong-Yeon, Holmström, Stefan   +2 more
core   +1 more source

Insights on microstructure evolution of austenite welded joints subjected to creep-fatigue loading

Journal of Materials Research and Technology
The crack growth behavior and microstructural evolution of 316H austenitic stainless steel welded joints subjected to load-controlled creep-fatigue crack growth at 550 °C was investigated in this study. A comprehensive analysis of the fracture mechanisms
Cong Li, Lei Zhao, Lianyong Xu, Yongdian Han, Kangda Hao   +4 more
doaj   +1 more source

Development of Advanced Creep Damage Constitutive Equations for Low CR Alloy Under Long-Term Service

Low Cr alloys are mostly utilized in structural components such as steam pipes, turbine generators and reactor pumps operating at high temperatures from 400℃ to 700℃ in nuclear power plants.
Xu, Qihua
core  

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source