Results 71 to 80 of about 542,843 (395)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Thermal creep effects of aluminum alloy cladding on the irradiation-induced mechanical behavior in U–10Mo/Al monolithic fuel plates

Nuclear Engineering and Technology, 2020
Three-dimensional finite element simulations are implemented for the in-pile thermo-mechanical behavior in U–Mo/Al monolithic fuel plates with different thermal creep rates of cladding involved. The numerical results indicate that the thickness increment
Xiaobin Jian, Shurong Ding
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Study on Creep Mechanical Properties of Non-Water Reacting Polyurethane Grouting Material

Advances in Materials Science and Engineering, 2022
Non-water reacting polyurethane is a new type of grouting material for support reinforcement and emergency rescue, whose creep mechanical behavior is directly related to the stability and safety of the reinforcement project.
Heng Liu, Mingyang Ren, Mingsheng Shi, Dengping Hu, Jianuo Tan   +4 more
doaj   +1 more source

Preliminary studies of the time-dependent shear and uniaxial tensile behaviour of oriented polymers [PDF]

, 1969
Summary The work reported in this memo is the initial stages of an investigation of the time-dependent behaviour of certain anisotropic polymers. In the first instance low density polyethylene with a transversely isotropic symmetry is being examined.
Clayton, D.
core  

Influence of Environment on Creep Properties of MC2 Single Crystal Superalloy at 1150°C [PDF]

, 2004
In order to reveal the effect of oxidation on thin blade walls, a new machine allowing tests up to 1250°C under controlled atmosphere has been designed.
Andrieu, Eric, Crabos, Fabrice, Dryepondt, Sébastien, Monceau, Daniel, Vernault, Cyril   +4 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Creep Model and Experimental Verification of Sandstone under the Coupled Effect of Chemical Corrosion and Temperature

Applied Sciences
The Nishihara creep model is an extremely effective method in the field of sandstone creep model research. However, the Nishihara creep model curve for sandstone under the marine environment (the coupled effect of chemical corrosion and temperature) does
Xia Xiu, Yong Wang, Ye Zhou, Geng Niu, Shijun Zhao, Degong Chang   +5 more
doaj   +1 more source

Evolution of interfacial dislocation network during anisothermal high-temperature creep of a nickel-based superalloy [PDF]

, 2011
The effect of thermal cycling creep on the dislocation networks at the γ/γ′ interfaces in the MC2 superalloy is investigated. Tensile creep tests were performed under thermal cycling and isothermal conditions at low stress (80 MPa) and high temperature ...
Coujou, Armand, Douin, Joël, Hantcherli, Muriel, Pettinari-Sturmel, Florence, Viguier, Bernard   +4 more
core   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source