Results 161 to 170 of about 29,556 (312)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Influence of Cryo-Processing and Post-SPD Annealing on Creep Behavior of CP Titanium. [PDF]

open access: yesMaterials (Basel), 2022
Dvorak J   +6 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Experimental Creep Tests on Concrete Made with Montmorillonite Nano Particles

open access: yes
The purpose of this research is to investigate and characterize the time-dependent behavior of new concrete compositions made by replacing cement with secondary aggregates — small clay particles — and then comparing them with control specimens made from ...
Sprince, Andīna   +2 more
core  

Creep and relaxation of nonlinear viscoelastic materials: with an introduction to linear viscoelasticity

open access: yes, 1976
Creep And Relaxation Of Nonlinear Viscoelastic Materials With An Introduction To Linear Viscoelasticity.Includes bibliographical references (pages 344-360).Includes indexes.Print version record.Electronic reproduction.Master and use copy.
Findley, William Nichols   +5 more
core  

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