Results 121 to 130 of about 17,423 (316)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Integrated approach for stress based lifing of aero gas turbine blades [PDF]

, 2013
In order to analyse the turbine blade life, the damage due to the combined thermal and mechanical loads should be adequately accounted for. This is more challenging when detailed component geometry is limited. Therefore, a compromise between the level of
Abu, Abdullahi Obonyegba
core  

History-sensitive accumulation rules for life-time prediction under variable loading

, 2011
This is the post-print version of the article. The official published version can be obtained from the link below - Copyright @ 2011 SpringerA general form of temporal strength conditions under variable creep loading is employed to formulate several new ...
Mikhailov, SE, S. E. Mikhailov, I. V. Namestnikova, Namestnikova, IV   +3 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The relative significance of internal damage mechanisms on the overall creep damage and ultimate failure of P91 steel

This paper reports research on the study of the relative significance of various internal creep damage mechanisms on the overall creep damage and lifetime of P91 steel.
Yang, Xin, Xu, Qiang, Lu, Zhongyu
core  

Subsection amplification cyclic deterioration mechanism of creep damaged coal

Meitan kexue jishu
Under the excavation effects of deep coal and rock, obvious creep damage is produced under the action of high stress for a long time and the sudden destabilization of the creep-damaged coal body induces rock burst disaster under the mining action in ...
Yangyang LI, Shichuan ZHANG, Baotang SHEN, Yadong XU, Jinming DANG, Jiaqi HOU   +5 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The development of computational FE system for creep damage analysis of weldment

A Finite Element Analysis (FEA) system was designed for the analysis of creep deformation and damage evolution in weldment. This project essentially consists of three parts which involves 1) transfer programme development, 2) numerical integration ...
Tan, Feng, Xu, Qiang, Barrans, Simon, Lu, Zhongyu   +3 more
core  

Creep: time‐dependent brittle deformation in rocks

, 2009
The characterization of time‐dependent brittle rock deformation is fundamental to understanding the long‐term evolution and dynamics of the Earth’s crust. The chemical influence of pore water promotes time‐dependent deformation through stress corrosion
Heap, M.J.
core  

Study of micro-mesoscopic creep damage on mudstone based on stress corrosion model

AIP Advances
To study the creep minor damage evolution process and creep damage mechanism of mudstone, this paper establishes a numerical model of a two-media triple cementation particle flow procedure of mudstone, reproduces the tender damage destruction process of ...
Bochao Ma, Guoli Zu, Xuehui Li, Xinshuai Shi, Guangzheng Xu, Xinzheng Qu   +5 more
doaj   +1 more source