Results 101 to 110 of about 17,423 (316)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Scientific ReportsCreep is one of the typical mechanical properties of clay, and studying the creep mechanical properties of clay is of great significance to construction projects in clay sites. This study conducted creep tests on Chengdu clay and found that the soil mass
Peng Wang, Yin Tang, Peng Ren, Hua Zhang
doaj +1 more source
Optimization of Burgers creep damage model of frozen silty clay based on fuzzy random particle swarm algorithm. [PDF]
Sci Rep, 2021 Yao Y, Cheng H, Lin J, Ji J.
europepmc +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The development of finite element software for creep damage analysis
Creep deformation and failure in high temperature structures is a serious problem for industry and is becoming even more so under the current increasing pressures of power, economics and sustainability.
Liu, Dezheng
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Microscopic cracks identification and nonlinear creep model of shale under creep-disturbance loading
Results in EngineeringIn this study, the action of creep damage evolution law of deep shale under the influence of disturbance was considered as the research object, and using a self-developed rock disturbance creep test rig, disturbance characteristics of rock creep ...
Jun-guang Wang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Development of Advanced Creep Damage Constitutive Equations for Low CR Alloy Under Long-Term Service
Low Cr alloys are mostly utilized in structural components such as steam pipes, turbine generators and reactor pumps operating at high temperatures from 400℃ to 700℃ in nuclear power plants.
Xu, Qihua
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The development of finite element software for creep deformation and damage analysis of weldment
This paper presents the development of finite element software for creep deformation and damage analysis of weldment. The development and benchmark test of the software under plane stress, plane strain, axisymmetric, and 3 dimensional cases were reported
Xu, Qiang +3 more
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