Results 81 to 90 of about 1,100 (217)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Creep damage model for deep salt rock under temperature and stress coupling effect

Meitan xuebao
As the demand on the construction salt rock storage increases in China, the shallow suitable deposits have been gradually exhausted, as such, the utilization shift from shallow to deep salt deposits is an inevitable trend.
Shengli ZHANG, Suguo XU, Ning XIAO, Jing LI, Chao LI   +4 more
doaj   +1 more source

The tertiary creep and necking of creep damaging solids

Acta Metallurgica, 1986
Abstract Tertiary creep and necking of bars composed of creep damaging material are investigated subject to the condition of constant applied load. The creep-damage constitutive model employed in the study is based on the concept of constrained cavity growth which characterizes the phenomenon of grain boundary cavitation in polycrystalline metals ...
openaire   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Subsection amplification cyclic deterioration mechanism of creep damaged coal

Meitan kexue jishu
Under the excavation effects of deep coal and rock, obvious creep damage is produced under the action of high stress for a long time and the sudden destabilization of the creep-damaged coal body induces rock burst disaster under the mining action in ...
Yangyang LI, Shichuan ZHANG, Baotang SHEN, Yadong XU, Jinming DANG, Jiaqi HOU   +5 more
doaj   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Study of micro-mesoscopic creep damage on mudstone based on stress corrosion model

AIP Advances
To study the creep minor damage evolution process and creep damage mechanism of mudstone, this paper establishes a numerical model of a two-media triple cementation particle flow procedure of mudstone, reproduces the tender damage destruction process of ...
Bochao Ma, Guoli Zu, Xuehui Li, Xinshuai Shi, Guangzheng Xu, Xinzheng Qu   +5 more
doaj   +1 more source

Insight into the Creep Damage Evolution in Water-Immersed Coal Pillars: Experiment and Numerical Model Investigation

Energies
Coal mine underground reservoirs play a significant role in energy utilization while also contributing to energy security. Prolonged immersion in mine water reduces the long-term strength of coal, subsequently leading to continuous creep damage in coal ...
Xueliang Li, Sihai Yi, Zheng Chen, Qingbiao Guo, Xiangjun Cai, Xin Guo, Haiyang Yi   +6 more
doaj   +1 more source