Results 71 to 80 of about 17,423 (316)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Creep model of roadway surrounding rock considering hardening effect and damage effect.

PLoS ONE
The influence of confining pressure on creep characteristics was analyzed by carrying out creep tests of rocks under different confining pressures. A new creep model of roadway surrounding rock considering the combined influence of hardening effect and ...
Hongmiao Lv
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Microradiography of creep damage in copper

NDT & E International, 1989
Abstract New advances in the radiographic technique have been made using high intensity synchroton radiation as the X-ray source. A 100-fold improvement in the resolution of the technique was realized, and features on the order of micrometers in size can now be routinely observed using “microradiography”.
J.E. Benci, D.P. Pope
openaire   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A Review of Creep Deformation and Rupture Mechanisms of Cr-Mo Alloy for the Development of Creep Damage Constitutive Equations under Lower Stress

, 2013
This paper presents a review of creep deformation and rupture mechanisms of low Cr-Mo alloy for the development of its creep damage constitutive equations under lower stress.
Xu, Qiang, Barrans, Simon, Xu, Qihua, Lou, Zhongyu, Lu, Zhongyu   +4 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Preliminary analysing of experimental data for the development of high Cr Alloy Creep damage Constitutive Equations

, 2012
This conference paper presents the current research of preliminary analysing of experimental data for the development of high Cr Alloy Creep damage Constitutive Equations (such as P91 alloy). Firstly, it briefly introduces the background of general creep
Xu, Qiang, An, Li Li, Xu, Donglai, An, Lili, Lu, Zhongyu   +4 more
core  

Literature Review on the Development of Computational Software System for Creep Damage Analysis for Weldment

, 2012
This paper reports a literature review on the development of computational software system for creep damage analysis for weldment. It starts with a brief review on the creep damage problem in weldment and the computational approach; identifies the need ...
Tan, Feng, Liu, De Zheng, Xu, Qihua, Lou, Zhongyu, Xu, Qi Hua, An, Lili, Pang, Y, Lu, Zhongyu, Liu, Dezheng, Lu, Zhong, Xu, Qiang, An, Li Li, Short, Michael, Lu, Zhong Yu, Short, Michael; id_orcid, Xu, Donglai, Pan, Yong Xin, Xu, Dong Lai   +17 more
core   +1 more source