Results 31 to 40 of about 17,423 (316)
Bone creep-fatigue damage accumulation
Journal of Biomechanics, 1989 Creep and fatigue tests were performed on human femoral cortical bone and the results were compared to a cumulative damage model for bone fracture. Fatigue tests in tension, compression, and reversed loading with a tensile mean stress were conducted at 2 Hz and 0.02 Hz.
W E, Caler, D R, Carter
openaire +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Micromechanics of creep fracture: simulation of intergranular crack growth [PDF]
, 1998 A computational model is presented to analyze intergranular creep crack growth in a polycrystalline aggregate in a discrete manner and based directly on the underlying physical micromechanisms.
Giessen, Erik van der, +4 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
GeofluidsTo investigate the creep behavior of deep-buried hard rocks under various initial damage conditions, standard dolomite specimens were subjected to conventional triaxial compression and creep tests under a confining pressure of 30 MPa.
Qingtao Peng +4 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
The Creep-Damage Model of Salt Rock Based on Fractional Derivative
Energies, 2018 The use of salt rock for underground radioactive waste disposal facilities requires a comprehensive analysis of the creep-damage process in salt rock. A computer-controlled creep setup was employed to carry out a creep test of salt rock that lasted as ...
Hongwei Zhou +4 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2015 It is very important to design a safe factor or estimating the remain lifetime for electric power plant components of steam pipes which mostly manufacture by high chromium steels and work at high temperature and low stress level.
Yang, Xin +5 more
core +1 more source