Results 151 to 160 of about 191,694 (304)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Features controlling the early stages of creep deformation of Waspaloy [PDF]
A model has been presented for describing primary and second stage creep. General equations were derived for the amount and time of primary creep. It was shown how the model can be used to extrapolate creep data.
Ferrari, A., Wilson, D. J.
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A new swelling - creep model for red-bed mudstone and its application
Frontiers in Earth ScienceIn the red-bed region, engineering structures often encounter safety risks due to the swelling and creep properties of mudstone. Presently, there is a deficiency in constitutive equations capable of characterizing mudstone behavior under combined stress ...
Hongyi Yan +5 more
doaj +1 more source
The creep behaviour of fibre reinforced plastics [PDF]
, 1969 Synopsis: This paper describes the tensile creep behaviour of fibre reinforced plastics under a uniaxial stress system. In particular, unidirectionally and bidirectionally reinforced plastics are considered for the relative ease with which samples of
Dootson, M.
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
A new creep model directly using tabulated test data and implemented in ansys [PDF]
, 2017 Nowadays plastics are increasingly used in highly stressed structures in all kinds of constructions. The time dependency, the so-called viscosity, is a crucial part of the material behavior of plastics. A typical form of viscosity is creep.
Rust, Wilhelm J.H., Shen, Kang
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source