Results 141 to 150 of about 191,694 (304)
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Energy-based nonlinear damage creep model considering the influence of the concrete creep rate
Frontiers in MaterialsIn order to study the influence of confining pressure on the deformation of concrete, triaxial compression and creep tests under different confining pressures are carried out using a combination of laboratory tests and theoretical analysis.
Lu Wang
doaj +1 more source
A Nonlinear Fractional Viscoelastic-Plastic Creep Model of Asphalt Mixture. [PDF]
Polymers (Basel), 2021 Zhang Y, Liu X, Yin B, Luo W.
europepmc +1 more source
A continuous damage model based on stepwise-stress creep rupture tests [PDF]
A creep damage accumulation model is presented that makes use of the Kachanov damage rate concept with a provision accounting for damage that results from a variable stress history.
Robinson, D. N.
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
A novel nonlinear creep model based on damage characteristics of mudstone strength parameters. [PDF]
PLoS One, 2021 Hu B, Cui A, Cui K, Liu Y, Li J.
europepmc +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
A creep cavity growth model for creep-fatigue life prediction of a unidirectional W/Cu composite [PDF]
A microstructural model was developed to predict creep-fatigue life in a (0)(sub 4), 9 volume percent tungsten fiber-reinforced copper matrix composite at the temperature of 833 K.
Halford, Gary R. +2 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Applied SciencesRock creep commonly appears in rock mass engineering, and it should be paid appropriate attention. In this paper, studies on creep constitutive models of rocks were reviewed, and it was found that the types of creep constitutive models can generally be ...
Pingyang Fan +6 more
doaj +1 more source