Results 121 to 130 of about 191,694 (304)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Research on Creep Constitutive Model for High Temperature Reactor Based on Neural Network
Yuanzineng kexue jishuThis research aims to develop a novel creep constitutive model, leveraging neural networks to precisely predict long-term creep behavior from short-term data.
ZHANG Fan, DAI Shoutong
doaj +1 more source
A Chemical Damage Creep Model of Rock Considering the Influence of Triaxial Stress. [PDF]
Materials (Basel), 2022 Chen Y +7 more
europepmc +1 more source
, 2003 Magnetic relaxation of high-pressure synthesized MgB$_2$ bulks with different thickness is investigated. It is found that the superconducting dia-magnetic moment depends on time in a logarithmic way; the flux-creep activation energy decreases linearly ...
Che, Guang-Can +6 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Scientific ReportsMuddy siltstone combines the characteristics of both sandstone and mudstone, and is prone to instability over time. To study the long-term stability of tunnel engineering in this stratum, this article taking the cross-river metro tunnel section as the ...
Huijuan Deng +5 more
doaj +1 more source
Research on the Creep Model of Deep Coal Roadway and Its Numerical Simulation Reproduction. [PDF]
Int J Environ Res Public Health, 2022 Zhang Q, Wang E, Ding Z.
europepmc +1 more source
Creep in fibre-reinforced polymer mat composites [PDF]
, 2007 Tensile creeps have been conducted upon a woven, glass-fibre laminated epoxy composite and a 0/90° cross ply, carbon fibre reinforced epoxy composite. For the laminate loading was aligned with a fibre direction.
Dix, S, Garner, AF, Rees, DWA
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Influence of Temperature, Humidity and Load Coupling on Mechanical Properties of Adhesive Joints and Establishment of Creep Model. [PDF]
Polymers (Basel), 2023 Tan W, Zhou Z, Na J, Mu W.
europepmc +1 more source