Results 111 to 120 of about 191,694 (304)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Creep Lifetime Modelling of 2.25Cr-1.6W Based on Creep Cavitation Model
Creep damage and the need of its modelling are introduced first. Then the steel investigated and the sources of experimental data are reported. A critical review on classical and recent new methods to calculate creep damage lifetime is included in literature review. The creep cavitation-based lifetime modelling method was expanded and applied to 3 sets
Feng, Shenhao, Lu, Joan, Xu, Qiang
openaire +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
A simplified log creep model for describing triaxial creep of mélange rocks. [PDF]
Heliyon, 2023 Oh H +6 more
europepmc +1 more source
Creep and creep rupture of laminated graphite/epoxy composites [PDF]
An incremental numerical procedure based on lamination theory is developed to predict creep and creep rupture of general laminates. Existing unidirectional creep compliance and delayed failure data is used to develop analytical models for lamina response.
Brinson, H. F. +2 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Bending creep of corrugated fibreboard in cycling relative humidity : a thesis presented in partial fulfilment of the requirements for the degree of Master of Applied Science in Agricultural Engineering at Massey University [PDF]
, 1999 Packaging of fresh fruit for export is a major use for corrugated fibreboard manufactured in New Zealand. However the cold and humid conditions used to preserve fruit quality are particularly detrimental to the strength of corrugated packaging.
McKenzie, Andrew David
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
The creep model based on nonlinear Newton body under different temperature conditions. [PDF]
Sci Rep, 2023 Zhang L, Wei X, Zhang Y.
europepmc +1 more source