Results 91 to 100 of about 191,694 (304)
A memory-dependent three-dimensional creep model for concrete
Case Studies in Construction MaterialsThe study of creep models for concrete is of great significance in analyzing and predicting the long-term stability of concrete structures. Based on the theory of memory-dependent derivatives, memory-dependent viscous dashpots that can describe the ...
Deng Zhang +4 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Multiscale modeling of upper mantle plasticity: From single-crystal rheology to multiphase aggregate deformation [PDF]
, 2014 We report a first application of an improved second-order (SO) viscoplastic self-consistent model for multiphase aggregates, applied to an olivine + diopside aggregate as analogue for a dry upper mantle peridotite deformed at 10 15 s 1 shear strain rate ...
BOLLINGER, Caroline +5 more
core +4 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Journal of Materials Research and Technology, 2020 A method is presented to firstly rationalise the short-term creep rupture strength data and then to predict the 100,000 h creep rupture strengths of a new 9Cr grade of martensitic creep resistant steels (G115) at different temperatures.
C.C. Jiang +4 more
doaj +1 more source
Simulations of aging and plastic deformation in polymer glasses
, 2007 We study the effect of physical aging on the mechanical properties of a model polymer glass using molecular dynamics simulations. The creep compliance is determined simultaneously with the structural relaxation under a constant uniaxial load below yield ...
G. C. Cianci +3 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Concrete Creep Analysis Method Based on a Long-Term Test of Prestressed Concrete Beam
Advances in Civil Engineering, 2020 Concrete creep plays a significant role in the long-term performance of the prestressed concrete structure. However, most of the existing prediction models cannot accurately reflect the in-site concrete creep in a bridge construction environment.
Mingfang Yang, Song Jin, Jinxin Gong
doaj +1 more source
Model B4 : multi-decade creep and shrinkage prediction of traditional and modern concretes [PDF]
, 2014 To improve the sustainability of concrete infrastructure, engineers face the challenge of incorporating new concrete materials while pushing the expected design life beyond 100 years.
Bazant, Z. P. +2 more
core +1 more source