Results 101 to 110 of about 191,694 (304)

Creep motion of a model frictional system [PDF]

, 2011
We report on the dynamics of a model frictional system submitted to minute external perturbations. The system consists of a chain of sliders connected through elastic springs that rest on an incline.
Baptiste Blanc, E. Clément, H. Bouasse, H. Moseley, Jean-Christophe Géminard, Luis A. Pugnaloni, M. P. Allen, T. Divoux   +7 more
core   +4 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Effect of Time and Stress on Creep Damage Characteristics of Cement-Based Materials

Buildings
In the realm of daily life, ensuring the safety of building structures and civil engineering projects remains a paramount research focus. The creep properties of materials significantly influence their long-term loading process.
Yifan Zhang, Tianxiang Sun, Mingze Qin, Dongxu Zhang, Nan Qin, Yongyan Wang   +5 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Creep and creep rupture of strongly reinforced metallic composites [PDF]

A creep and creep damage theory is presented for metallic composites with strong fibers. Application is to reinforced structures in which the fiber orientation may vary throughout but a distinct fiber direction can be identified locally (local transverse
Binienda, W. K., Miti-Kavuma, M., Robinson, D. N.   +2 more
core   +1 more source

Creep of superconducting vortices in the limit of vanishing temperature: A fingerprint of off-equilibrium dynamics

, 2001
We theoretically study the creep of vortex matter in superconductors. The low temperatures experimental phenomenology, previously interpreted in terms of ``quantum tunnelling'' of vortices, is reproduced by Monte Carlo simulations of a purely ``classical'
Jensen, Henrik Jeldtoft, Nicodemi, Mario
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Creep damage constitutive model of rock based on the mechanisms of crack-initiated damage and extended damage

Underground Space
Since the classical element model cannot describe the nonlinear characteristics of rock during the entire compressive creep process, nonlinear elements and creep damage are generally introduced in the model to resolve this issue.
Tianbin Li, Chao Chen, Feng Peng, Chunchi Ma, Mou Li, Yixiang Wang   +5 more
doaj   +1 more source

A creep model for metallic composites based on matrix testing: Application to Kanthal composites [PDF]

An anisotropic creep model is formulated for metallic composites with strong fibers and low to moderate fiber volume percent (less than 40 percent).
Arnold, S. M., Bartolotta, Paul A., Binienda, W. K., Robinson, D. N.   +3 more
core   +1 more source