Results 131 to 140 of about 191,694 (304)

Evaluation of Three Constitutive Models for the Prediction of Hastelloy X Elevated Temperature Cyclic Response [PDF]

open access: yes, 1983
The approach for the method development assumes that, for a thermally loaded structure, the overall strain history is defined by linear elastic analysis.
Moreno, V.
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Anisotropic time-dependent behaviors of shale under direct shearing and associated empirical creep models

open access: yesJournal of Rock Mechanics and Geotechnical Engineering
Understanding the anisotropic creep behaviors of shale under direct shearing is a challenging issue. In this context, we conducted shear-creep and steady-creep tests on shale with five bedding orientations (i.e.
Yachen Xie   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

A generalization of the Becker model in linear viscoelasticity: Creep, relaxation and internal friction

open access: yes, 2018
We present a new rheological model depending on a real parameter $\nu \in [0,1]$ that reduces to the Maxwell body for $\nu=0$ and to the Becker body for $\nu=1$.
Mainardi, Francesco   +2 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Study on shear creep model of calcareous sand in China South Sea

open access: yesFrontiers in Earth Science
The creep characteristics of calcareous sand have an important impact on the stability of the structures on the coral islands in the South China Sea. Among the existing creep models for calcareous sand, fewer models consider the particle fragmentation of
Bin Tang   +3 more
doaj   +1 more source

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