Creosote bush lignans for human disease treatment and prevention: Perspectives on combination therapy [PDF]
Journal of Traditional and Complementary Medicine, 2015 The medicinal properties of the most successful plant in the deserts of the western hemisphere, the creosote bush (Larrea tridentata), are evidenced by the long traditional usage of the plants by the Native Americans Indian tribes in Southwestern North ...
John Gnabre, Robert Bates, Ru Chih Huang
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Creosote Bush (Larrea tridentata) Extract Assessment as a Green Antioxidant for Biodiesel [PDF]
Molecules, 2019 In this work, the antioxidant properties of methanolic extract of Larrea tridentata were assessed through the free radical scavenging method, ferric reducing antioxidant power and oxygen radical absorbance capacity.
Carlos A. Sagaste +8 more
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Polyploidy in creosote bush (Larrea tridentata) shapes the biogeography of specialist herbivores. [PDF]
J Biogeogr, 2019 Whole‐genome duplication (polyploidy) can influence the biogeography and ecology of plants that differ in ploidy level (cytotype). Here, we address how two consequences of plant polyploidy (parapatry of cytotypes and altered species interactions) shape ...
O'Connor TK, Laport RG, Whiteman NK.
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Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. [PDF]
PLoS ONE, 2015 Nordihydroguaiaretic acid (NDGA), the main metabolite of Creosote bush, has been shown to have profound effects on the core components of the metabolic syndrome (MetS), lowering blood glucose, free fatty acids (FFA) and triglyceride (TG) levels in ...
Haiyan Zhang +11 more
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The desert woodrat (Neotoma lepida) induces a diversity of biotransformation genes in response to creosote bush resin. [PDF]
Comp Biochem Physiol C Toxicol PharmacolLiver biotransformation enzymes have long been thought to enable animals to feed on diets rich in xenobiotic compounds. However, despite decades of pharmacological research in humans and rodents, little is known about hepatic gene expression in ...
Greenhalgh R +5 more
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Creosote bush-derived NDGA attenuates molecular and pathological changes in a novel mouse model of non-alcoholic steatohepatitis (NASH). [PDF]
Mol Cell Endocrinol, 2019 Creosote bush (Larrea tridentata)-derived nordihydroguaiaretic acid (NDGA) was shown to have profound effects on the core components of metabolic syndrome.
Han L +8 more
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Creosote Bush (Larrea tridentata) Improves Insulin Sensitivity and Reduces Plasma and Hepatic Lipids in Hamsters Fed a High Fat and Cholesterol Diet. [PDF]
Front Pharmacol, 2016 Creosote bush, Larrea tridentata (Sesse y Moc. Ex DC, Zygophyllaceae) is a shrub found in the deserts of Northern Mexico and Southwestern United States. In traditional medicine, it is used to treat a variety of illnesses including type 2 diabetes.
Del Vecchyo-Tenorio G +3 more
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Dietary-Driven Gene Expansion. [PDF]
Clin Pharmacol TherGene duplication has been shown to drive molecular evolution, with dietary pressures expanding detoxification genes across species. In humans, CYP2D6 gene duplications enhance alkaloid and drug metabolism, reflecting ancient dietary adaptations. Similarly, tobacco‐feeding aphids amplify CYP6CY3 for nicotine and insecticide resistance, and as recently ...
Ingelman-Sundberg M.
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Rodents consuming the same toxic diet harbor a unique functional core microbiome [PDF]
Animal MicrobiomeGut microbiota are intrinsic to an herbivorous lifestyle, but very little is known about how plant secondary compounds (PSCs), which are often toxic, influence these symbiotic partners.
Tess E. Stapleton +3 more
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FermentationCreosote bush (Larrea tridentata), a shrub distributed across approximately 19 Mha of arid North American regions, has traditional applications in folk medicine due to the presence of bioactive molecules such as nordihydroguaiaretic acid (NDGA) and ...
Alonso Ascacio-Valdés +3 more
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