Results 151 to 160 of about 75,389 (334)

CRES : a Competitive Reactive Eco-System Agent Architecture

, 1998
This paper presents CRES, a learning reactive agent architecture for managing limited resources. CRES achieves complicated behavior with simple components, minimizes the need for explicit instructions, and can handle learning without the need for ...
Synnes, Kåre,, Wiss, Ulrika,, Schefström, Dick,, Carr, David,   +3 more
core  

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

Le cycle des septuplés. Examen de quelques versions folkloriques et hagiographiques celtiques (Deuxième partie: légendes pieuses, traditions topographiques et héritage mythique)

Boletín de Literatura Oral, 2013
RÉSUMÉ: En marge du culte breton des Sept Saints, toute une série de légendes topographiques de tradition orale, qui se réfèrent de près ou de loin, voire pas du tout, à ce cycle canonique, parlent des naissances gémellaires et des enfances accidentées ...
François Delpech
doaj  

Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations

Genome Medicine
Background Genome-wide association studies (GWAS) have identified hundreds of loci underlying adult-onset asthma (AOA) and childhood-onset asthma (COA).
Xiaoyuan Zhong, Robert Mitchell, Christine Billstrand, Emma E. Thompson, Noboru J. Sakabe, Ivy Aneas, Isabella M. Salamone, Jing Gu, Anne I. Sperling, Nathan Schoettler, Marcelo A. Nóbrega, Xin He, Carole Ober   +12 more
doaj   +1 more source

The Cre/lox system: Cre-ating unintended damage [PDF]

American Journal of Physiology-Renal Physiology, 2019
openaire   +2 more sources

Nautical tourism on the island of Cres

Otok Cres, kao popularna obalna destinacija s bogatom tradicijom u turizmu, već dugo privlači posjetitelje svojim prirodnim ljepotama, osobito tijekom ljetnih mjeseci.
Jedrejčić, Monika
core   +1 more source

The budget process in Town of Cres

, 2018
Tema ovog diplomskog rada su proračunski procesi u jedinicama lokalne samouprave. Kao primjer navedena je jedinica lokalne samouprave Grad Cres odnosno proračun Grada Cresa za 2016.godinu. Grad Cres smješten na otoku Cresu u Primorsko-goranskoj županiji.
Dorčić, Dino
core  

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

Advanced Science, EarlyView.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng, Mengdie Cao, Hai Huang, Shuya Bai, Luyao Liu, Jingwen Liang, Haochen Cui, Qiaodan Zhou, Shiru Chen, Jiamei Jiang, Luoxia Liu, Zhou Luan, Wei Chen, Si Xiong, Ronghua Wang, Bin Cheng, Yuchong Zhao   +16 more
wiley   +1 more source

A High‐Throughput Live Imaging Platform to Investigate Circuit‐Dependent Regulation of Circadian Rhythms in Brain Tissue

Advanced Science, EarlyView.
Biological rhythms coordinate physiology, from genes to behavior. Study of circadian rhythms in brain tissue is constrained by limited throughput and spatial and temporal information quality. A new platform for high‐throughput, long‐term multiplexed fluorescent live imaging of circadian rhythms in brain slices is introduced.
Marco Ferrari, Natalie Ness, Julieta Acosta, Marco Brancaccio   +3 more
wiley   +1 more source