Results 31 to 40 of about 2,561,602 (268)

Cranial Neural Crest Cells and Their Role in the Pathogenesis of Craniofacial Anomalies and Coronal Craniosynostosis

Journal of Developmental Biology, 2020
Craniofacial anomalies are among the most common of birth defects. The pathogenesis of craniofacial anomalies frequently involves defects in the migration, proliferation, and fate of neural crest cells destined for the craniofacial skeleton.
Erica M. Siismets, Nan E. Hatch
doaj   +1 more source

POLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4

Genetics in Medicine, 2019
Treacher Collins syndrome (TCS) is a rare autosomal dominant mandibulofacial dysostosis, with a prevalence of 0.2–1/10,000. Features include bilateral and symmetrical malar and mandibular hypoplasia and facial abnormalities due to abnormal neural crest ...
E. Sanchez, B. Laplace-Builhé, F. T. Mau-Them, E. Richard, A. Goldenberg, Tomi L. Toler, T. Guignard, V. Gatinois, M. Vincent, C. Blanchet, A. Boland, M. Bihoreau, J. Deleuze, R. Olaso, Walton Nephi, H. Lüdecke, J. Verheij, F. Moreau-Lenoir, F. Denoyelle, J. Rivière, J. Laplanche, M. Willing, G. Captier, F. Apparailly, D. Wieczorek, C. Collet, F. Djouad, D. Geneviève   +27 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Uncommon skeletal findings in systemic sclerosis (scleroderma)

South African Journal of Radiology, 2002
Scleroderma or progressive systemic sclerosis is a diffuse disease characterised by excessive deposition of collagen and small-vessel arteritis. Systemic sclerosis is divided into two groups. 1.
Betsie van der Walt, Irma van de Werke, Zarina Lockhat   +2 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

CREST Syndrome in Systemic Sclerosis Patients – Is Dystrophic Calcinosis a Key Element to a Positive Diagnosis?

Journal of Inflammation Research, 2022
Carmen Bobeica,1,* Elena Niculet,1,2 Mihaela Craescu,1 Elena-Laura Parapiru,3,* Carmina Liana Musat,1,* Ciprian Dinu,4,* Iulia Chiscop,5,* Luiza Nechita,3,* Mihaela Debita,6,* Victorita Stefanescu,6,* Ioana Anca Stefanopol,
Bobeica C, Niculet E, Craescu M, Parapiru EL, Musat CL, Dinu C, Chiscop I, Nechita L, Debita M, Stefanescu V, Stefanopol IA, Nechifor A, Pelin AM, Balan G, Chirobocea S, Vasile CI, Tatu AL   +16 more
doaj  

On the Potential Role of the Neural Crest Cells in Integrating Pigmentation Into Behavioral and Physiological Syndromes

Frontiers in Ecology and Evolution, 2020
Melanin pigments color the integument of vertebrates with shades of rufous, gray, and black. In numerous wild species, melanin-based coloration associates to different behavioral, physiological, and morphological traits, yet the proximate basis of such ...
Luis M. San-Jose, Alexandre Roulin
doaj   +1 more source

Modularity patterns in mammalian domestication: Assessing developmental hypotheses for diversification

Evolution Letters, 2021
The neural crest hypothesis posits that selection for tameness resulted in mild alterations to neural crest cells during embryonic development, which directly or indirectly caused the appearance of traits associated with the “domestication syndrome” (DS).
Laura A. B. Wilson, Ana Balcarcel, Madeleine Geiger, Laura Heck, Marcelo R. Sánchez‐Villagra   +4 more
doaj   +1 more source

Two induced pluripotent stem cell (iPSC) lines derived from patients affected by Waardenburg syndrome type 1 retain potential to activate neural crest markers

Stem Cell Research, 2023
Waardenburg syndrome type 1 (WS1), a rare genetic disease characterized by pigmentation defects and mild craniofacial anomalies often associated with congenital deafness is caused by heterozygous mutations in the PAX3 gene (2q36.1). We have generated two
Mansour Alkobtawi, Patrick Pla, Brigitte Onteniente, Subham Seal, Véronique Pingault, Sandrine Marlin, Anne H. Monsoro-Burq   +6 more
doaj   +1 more source