Results 11 to 20 of about 22,988 (222)

Developing neuropalliative care for sporadic Creutzfeldt-Jakob Disease

Prion, 2022
We aimed to identify targets for neuropalliative care interventions in sporadic Creutzfeldt-Jakob disease by examining characteristics of patients and sources of distress and support among former caregivers.
Krista L. Harrison, Sarah B. Garrett, Joni Gilissen, Michael J. Terranova, Alissa Bernstein Sideman, Christine S. Ritchie, Michael D. Geschwind   +6 more
doaj   +2 more sources

Creutzfeldt-Jakob disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2013
Creutzfeldt⁃Jakob disease (CJD) is a degenerative central nervous system (CNS) disease caused by infection of prion protein (PrP), with clinical features including short course, rapid development and 100% mortality.
Lin WANG, Jian-rong LIU
doaj   +5 more sources

Efficient transmission and characterization of creutzfeldt-jakob disease strains in bank voles.

PLoS Pathogens, 2006
Transmission of prions between species is limited by the "species barrier," which hampers a full characterization of human prion strains in the mouse model.
Romolo Nonno, Michele A Di Bari, Franco Cardone, Gabriele Vaccari, Paola Fazzi, Giacomo Dell'Omo, Claudia Cartoni, Loredana Ingrosso, Aileen Boyle, Roberta Galeno, Marco Sbriccoli, Hans-Peter Lipp, Moira Bruce, Maurizio Pocchiari, Umberto Agrimi   +14 more
doaj   +3 more sources

Interlaboratory validation of cerebrospinal fluid α‐synuclein quantification in the diagnosis of sporadic Creutzfeldt‐Jakob disease [PDF]

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018
Introduction Cerebrospinal fluid α‐synuclein level is increased in sporadic Creutzfeldt‐Jakob disease cases. However, the clinical value of this biomarker remains to be established.
Niels Kruse, Amanda Heslegrave, Vandana Gupta, Martha Foiani, Anna Villar‐Piqué, Matthias Schmitz, Sylvain Lehmann, Charlotte Teunissen, Kaj Blennow, Henrik Zetterberg, Brit Mollenhauer, Inga Zerr, Franc Llorens   +12 more
doaj   +2 more sources

Creutzfeldt-Jakob Disease After the Coronavirus Disease-2019 Vaccination

Türk Yoğun Bakim Derneği Dergisi, 2022
Reports of neurological problems are increasing for the clinical presentation of coronavirus disease-2019 (COVID-19). The clinical presentation reported in this study seemed to be a combination of nonspecific complications of the systemic disease ...
Anıl Kuvandık, Ecenur Özcan, Simay Karaduman, Hülya Sungurtekin   +3 more
doaj   +2 more sources

Creutzfeldt–Jakob disease: A case report [PDF]

Radiology Case Reports
Creutzfeldt–Jakob Disease (CJD) is a rare, fatal neurodegenerative disorder that is caused by prion proteins. Patients often present with rapidly progressive dementia, ataxia, myoclonus, memory impairment, visual problems, and changes in personality.
Fahad Rasool Butt, HBSc, Thanansayan Dhivagaran, HBSc, Syed Naqvi, MD, FRCPC, DABR   +2 more
doaj   +2 more sources

Understanding the Phenotypic Heterogeneity Within the Sporadic Creutzfeldt-Jakob Disease MV1 Subtype. [PDF]

Neuropathol Appl Neurobiol
We present the clinical, pathological and prion biophysical features of three atypical cases of the MV1 subtype of sporadic Creutzfeldt–Jakob disease (sCJD). We propose that these heterozygous cases exist on a spectrum ranging from MM1‐like to VV1‐like phenotypes and recommend that subtyping be performed at pH 6.9 to avoid missing atypical or mixed ...
Nemani SK, Cortez LM, Myskiw J, Cali I, Booth SA, Jansen GH, Sim VL.   +6 more
europepmc   +2 more sources

Epilepsia partialis continua as the presenting manifestation of Creutzfeldt-Jakob disease: A video-polygraphic clinical vignette. [PDF]

Epileptic Disord
Epileptic Disorders, Volume 28, Issue 3, Page 920-924, June 2026.
Cutellè R, Pascarella A, Santoro A, Cianci V, Mammì A, Tripodi GG, Prestandrea C, Gasparini S, Ferlazzo E.   +8 more
europepmc   +2 more sources

A Practice Framework for Genetic Testing in Asymptomatic Relatives of Patients With Creutzfeldt-Jakob Disease: Experience and Insights From Israel. [PDF]

Eur J Neurol
Presymptomatic genetic testing for genetic Creutzfeldt‐Jakob disease requires careful balancing of autonomy, psychological preparedness, and potential familial implications. Based on multidisciplinary experience in Israel, we propose a structured framework including pre‐test counseling, psychological appraisal, genetic testing, in‐person results ...
Shir D, Bregman N, David AB, Nathan T, Goldstein O, Gurevich T, Thaler A, Mirelman A, Shiner T, Weisz MG, Shkedi-Rafid S, Ganz G, Shani H, Pras E, Chorin O, Sorkin G, Markus-Bustani K, Merhavi SK, Shechory-Stahl M, Sharav MY, Dicastro M, Trigubov D, Barel D, Kahana E, Fellner A, Korczyn A, Feldman HB, Greenbaum L, Omer N.   +28 more
europepmc   +2 more sources

Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease

Acta Neuropathologica Communications, 2020
Mitochondrial dysfunction has been implicated in multiple neurodegenerative diseases but remains largely unexplored in Creutzfeldt-Jakob disease. Here, we characterize the mitochondrial respiratory chain at the individual neuron level in the MM1 and VV2 ...
Irene H. Flønes, Gerda Ricken, Sigrid Klotz, Alexandra Lang, Thomas Ströbel, Christian Dölle, Gabor G. Kovacs, Charalampos Tzoulis   +7 more
doaj   +1 more source