Results 41 to 50 of about 48,713 (266)

Chronic Central Adrenal Insufficiency in a Patient With Remote Traumatic Brain Injury and an Apparently Adequate Standard-Dose ACTH Response: A Case Report. [PDF]

Clin Case Rep
ABSTRACT In patients with a remote history of traumatic brain injury, central adrenal insufficiency may remain unrecognized for decades. An apparently adequate response to standard‐dose ACTH stimulation should not preclude further evaluation of the hypothalamic–pituitary–adrenal axis when clinical and biochemical findings continue to suggest adrenal ...
Kageyama K, Sato K, Yamagata S, Tasso M, Nakada Y, Sawada S.   +5 more
europepmc   +2 more sources

Multi‐Layer Transcriptomic Comparison Across Human, Pig, and Mouse Informs Tissue‐ and Trait‐Specific Animal Model Selection

Advanced Science, EarlyView.
We integrated RNA‐seq data from humans, pigs, and mice across 15 matched tissues based on 14 910 one‐to‐one orthologous genes. Cross‐species similarity was systematically evaluated across multiple regulatory layers, including global co‐expression conservation, co‐expression networks, tissue‐specific programs, and 3D genome architecture.
Jingwen Dou, Yong Liao, Xiong Shen, Xin Huang, Zhenshuang Tang, Yuwei Gou, Huajun Zhou, Jingya Xu, Hong Liu, Yue Wang, Keke Liang, Jia Liu, Xiao Zhang, Chenyao Li, Shangjian Wang, Liangliang Fu, Lilin Yin, Xinyun Li, Shuhong Zhao, Xiaolei Liu, Jingjin Li, Yuhua Fu   +21 more
wiley   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Brain corticotropin releasing hormone and stress reactivity

Интегративная физиология, 2021
The hypothalamic-pituitary-adrenocortical axis is one of the main components of stress adaptation. Corticotropin-releasing hormone (CRH) coming from the nucleus paraventricularis hypothalami (PVN) is the canonical central regulator of the axis.
Krisztina Bánrévi, Tiago Chaves, Pedro Correia, Csilla Lea Fazekas, Adrienn Szabó, Bibiána Török, Dóra Zelena   +6 more
doaj   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

The involvement of central corticotropin-releasing hormone and its receptors in sleep-wake regulation of mice [PDF]

, 2010
The corticotropin-releasing hormone (CRH) is widely recognised as the major activator of the hypothalamic-pituitary-adrenocortical (HPA) axis, thereby mediating neuroendocrine, autonomic, and behavioural responses to stress.
Romanowski, C., Romanowski, Christoph
core  

The musculature and skeleton of the pelvic fin of the crocodile shark, Pseudocarcharias kamoharai (Matsubara, 1936) (Elasmobranchii: Lamniformes): Morphology and sexual dimorphism

The Anatomical Record, EarlyView.
This work brings new information on the sexual characteristics of the crocodile shark (Pseudocarcharias kamoharai) exploring the pelvic fin musculature, as well as the siphon sac and the musculature and skeleton of the clasper. Our paper is the first to point out clearly the sexual dimorphism related exclusively to the pelvic fin musculature in males ...
Laura F. Mianutti, Kenshu Shimada, João Paulo C. B. da Silva   +2 more
wiley   +1 more source

Landslides and vegetation fragmentation drive hydro-sedimentary hazards and urban flooding in Uvira

Discover Environment
Across the mountainous regions of the East African Rift, interactions between human activities and extreme rainfall events can intensify urban hydro-geomorphological hazards.
Patient Tomombwa Kumbusa, Pascal Masilya Mulungula, Silvanos Fiama Bondo, Prudence Bararunyeretse, Benjamin Mukasani, Ruffin Safari Rukahusa, Déo Mushagalusa Cirhuza   +6 more
doaj   +1 more source

Single-cell morphological characterization of CRH neurons throughout the whole mouse brain

BMC Biology, 2021
Background Corticotropin-releasing hormone (CRH) is an important neuromodulator that is widely distributed in the brain and plays a key role in mediating stress responses and autonomic functions.
Yu Wang, Pu Hu, Qinghong Shan, Chuan Huang, Zhaohuan Huang, Peng Chen, Anan Li, Hui Gong, Jiang-Ning Zhou   +8 more
doaj   +1 more source

Behavioural Activation Produced by CRH but Not α-Helical CRH (CRH-Receptor Antagonist) when Microinfused into the Central Nucleus of the Amygdala under Stress-Free Conditions [PDF]

, 1995
The central nucleus of the amygdala (CeA) is known to be involved in the regulation of autonomic, neuroendocrine, and behavioural responses in stress situations.
Baauw, A.D., Bohus, B., Koolhaas, J.M., Wiersma, A.   +3 more
core   +1 more source