Results 41 to 50 of about 16,408 (183)

Zuchtleistung stoffwechselgesunder und diabetischer Chinesischer Streifenhamster (Cricetulus griseus) [PDF]

Diabetologia, 1970
Die Zuchtleistungen stoffwechselgesunder und erblich diabetischer Chinesischer Streifen-hamster wurden verglichen. Wurfgrose und Wurffolge hatten keinen Einflus auf das Geburtsgewicht und das Wachstum bis zum Absetzen. Zwischen Nachkommen stoffwechselgesunder und diabetischer Muttertiere bestand kein Unterschied hinsichtlich der Korpergewichte, die ...
O. Loge, H. Steinbeck
openaire   +1 more source

An In Vitro and In Vivo Assessment of the Genotoxic Potential of Maizinol (UP165), a Zea mays Leaf Extract

Journal of Applied Toxicology, Volume 46, Issue 3, Page 950-960, March 2026.
ABSTRACT Benzoxazinoids are secondary metabolites produced in monocotyledons and some dicotyledons from the Acanthaceae, Ranunculaceae, Scrophulariaceae, Plantaginaceae, and Lamiaceae families. Benzoxazinoids are commonly consumed in bread and cereal products that have been ingested for decades, which supports the safe use of benzoxazinoids as food ...
J. Kyle Weston, Barry S. Lynch, James A. Akingbasote   +2 more
wiley   +1 more source

Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothermic Conditions

Biotechnology and Bioengineering, Volume 123, Issue 1, Page 5-25, January 2026.
Proteomic analysis of CHO cells under mild hypothermia (31°C) reveals ER stress responses, ubiquitination dynamics, and adaptive mechanisms. Magnetic immuno‐affinity enrichment and mass spectrometry highlight protein regulation differences in non‐producer versus producer cells, offering insights for optimising biopharmaceutical production of IgG1 and ...
David Ryan, Christiana‐Kondylo Sideri, Michael Henry, Selvaprakash Karuppuchamy, Esen Efeoglu, Paula Meleady   +5 more
wiley   +1 more source

Computational Approaches for Pathway‐Centric Analysis of Protein Post‐Translational Modifications

PROTEOMICS, Volume 25, Issue 21-22, Page 41-61, November 2025.
ABSTRACT Protein function is dynamically modulated by post‐translational modifications (PTMs). Many different types of PTMs can nowadays be identified and quantified at a large scale using mass spectrometry. It is well known that many PTMs have an effect on protein function and cellular processes, and they should be studied not in isolation, but in the
Julian Müller, Bernhard Kuster, Matthew The   +2 more
wiley   +1 more source

Critical Evaluation of Methods for the Identification of Aneugens

Environmental and Molecular Mutagenesis, Volume 66, Issue 8, Page 412-424, October 2025.
ABSTRACT The genotoxic potential of chemicals must be evaluated in regulatory safety assessment settings, including but not limited to, the development of new pharmaceuticals, industrial chemicals, food and cosmetic ingredients, and agrochemicals. Initial assessment of the chromosome‐damaging potential of chemicals is often conducted in mammalian cells
Xiaowen Sun, Stephen D. Dertinger, Azeddine Elhajouji, Daniel J. Roberts, Jan van Benthem, Maik Schuler, Shambhu Roy, Alexandra Taraboletti, Connie L. Chen   +8 more
wiley   +1 more source

miR-19b-3p regulated by estrogen controls lipid synthesis through targeting MSMO1 and ELOVL5 in LMH cells

Poultry Science
: miR-19b-3p is reported to undertake various biological role, while its function and action mechanism in chicken hepatic lipid metabolism is unclear. Conservation analysis and tissue expression pattern of miR-19b-3p and its target gene were evaluated ...
Qihui Jia, Yuzhu Cao, Mengmeng Zhang, Yuxin Xing, Tian Xia, Yulong Guo, Yaxin Yue, Xin Li, Xiaojun Liu, Yanhua Zhang, Donghua Li, Zhuanjian Li, Yadong Tian, Xiangtao Kang, Hong Li   +14 more
doaj   +1 more source

Flux Sampling Suggests Metabolic Signatures of High Antibody‐Producing CHO Cells

Biotechnology and Bioengineering, Volume 122, Issue 7, Page 1898-1913, July 2025.
ABSTRACT Chinese hamster ovary (CHO) cells remain the industry standard for producing numerous therapeutic proteins, particularly monoclonal antibodies (mAbs). However, achieving higher recombinant protein titers remains an ongoing challenge and a fundamental understanding of the cellular mechanism driving improved bioprocess performance remains ...
Kate E. Meeson, Joanne Watson, Susan Rosser, Ellie Hawke, Andrew Pitt, Tessa Moses, Leon Pybus, Magnus Rattray, Alan J. Dickson, Jean‐Marc Schwartz   +9 more
wiley   +1 more source

Phosphoproteomics for studying signaling pathways evoked by hormones of the renin‐angiotensin system: A source of untapped potential

Acta Physiologica, Volume 241, Issue 2, February 2025.
Abstract The Renin‐Angiotensin System (RAS) is a complex neuroendocrine system consisting of a single precursor protein, angiotensinogen (AGT), which is processed into various peptide hormones, including the angiotensins [Ang I, Ang II, Ang III, Ang IV, Ang‐(1–9), Ang‐(1–7), Ang‐(1–5), etc] and Alamandine‐related peptides [Ang A, Alamandine, Ala‐(1–5)],
Igor Maciel Souza‐Silva, Victor Corasolla Carregari, U. Muscha Steckelings, Thiago Verano‐Braga   +3 more
wiley   +1 more source

Prolonged exposure to insulin might cause epigenetic alteration leading to insulin resistance

FEBS Open Bio, Volume 15, Issue 1, Page 81-93, January 2025.
Our research identifies one possible mechanism of insulin resistance observed in type II diabetes. We show that even short‐term exposure to elevated levels of insulin without glucose stimulation (low glucose conditions) could lead to insulin resistance and the underlying cause could be epigenetic alterations leading to impaired PI3/AKT signalling ...
Shehnaz Bano, Shyam More, Dattatray S. Mongad, Abdul Khalique, Dhiraj P. Dhotre, Manoj K. Bhat, Vasudevan Seshadri   +6 more
wiley   +1 more source

Multiple sequence alignment of the amino acid sequence of unigene 25995 with other known neprilysin or neprilysin-like proteins.

, 2015
The aligned sequences are as follows: Oryctolagus cuniculus neprilysin (NP_001095155), Equus przewalskii neprilysin isoform X2 (XP_008519227), Loxodonta africana neprilysin (XP_003416187), Cricetulus griseus neprilysin (XP_007625698), Peromyscus ...
Liming Zhang (213971), Qian He (248656), Dan Liu (108669), Zengliang Ruan (563479), Yonghong Zhou (42434), Qianqian Wang (494839), Guoyan Liu (563480)   +6 more
core   +1 more source