Results 111 to 120 of about 10,763 (250)

Crimean-Congo Hemorrhagic Fever: Tick-Host-Virus Interactions [PDF]

Frontiers in Cellular and Infection Microbiology, 2017
Crimean-Congo hemorrhagic fever virus (CCHFV) is transmitted to humans by bite of infected ticks or by direct contact with blood or tissues of viremic patients or animals. It causes to humans a severe disease with fatality up to 30%. The current knowledge about the vector-host-CCHFV interactions is very limited due to the high-level containment ...
Anna Papa, Katerina Tsergouli, Katerina Tsioka, Ali Mirazimi, Ali Mirazimi, Ali Mirazimi   +5 more
openaire   +3 more sources

A TLR8 Variant Identified From Whole Exome Sequencing as a Sepsis‐Prone Mutation

FASEB BioAdvances, Volume 8, Issue 4, April 2026.
Whole‐exome sequencing of sepsis patients identified a recurrent high‐impact TLR8 rs3764880 variant enriched in bacterial sepsis. Single‐cell transcriptomics localized elevated TLR8 expression to non‐classical monocytes, while bulk RNA‐seq and functional assays demonstrated enhanced IFN‐β responses following TLR8 stimulation.
Fahd Alhamdan, Stefano Gianoli, Xioahui Han, Sophia Koutsogiannaki   +3 more
wiley   +1 more source

Immunization with DNA Plasmids Coding for Crimean-Congo Hemorrhagic Fever Virus Capsid and Envelope Proteins and/or Virus-Like Particles Induces Protection and Survival in Challenged Mice

Journal of Virology, 2017
Crimean-Congo hemorrhagic fever virus (CCHFV) is a bunyavirus causing severe hemorrhagic fever disease in humans, with high mortality rates. The requirement of a high-containment laboratory and the lack of an animal model hampered the study of the immune
J. Hinkula, S. Devignot, Sara Åkerström, H. Karlberg, E. Wattrang, S. Bereczky, M. Mousavi‐Jazi, C. Risinger, G. Lindegren, C. Vernersson, J. Pawęska, P. J. van Vuren, O. Blixt, A. Brun, F. Weber, A. Mirazimi   +15 more
semanticscholar   +1 more source

Assessment of Butchers' Awareness, Attitude, and Occupational Practices Toward Crimean‐Congo Hemorrhagic Fever (CCHF) in Kabul, Afghanistan: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Crimean‐Congo hemorrhagic fever (CCHF) is a viral disease with a fatality rate up to 40%, transmitted through tick bites and infected livestock. Afghanistan's livestock farming and limited public health infrastructure increase infection risks.
Fazel Ahmad Muhammadi, Sayed Abdul Wahab Sadat, Rohullah Sakhi, Abdul Qaher Jasoor, Aimal Mohammadi, Niaz Mohammad Azizi, Hassan Hassanpoor, Abdulhanan Hanafi, Nader Qambari, Abdul Qayoom Joyenda, Mohammad Hussain Joya   +10 more
wiley   +1 more source

Not Every Country Can Absorb a Shock: Unequal Capacity to Withstand World Health Organization Aid Cuts

Public Health Challenges, Volume 5, Issue 1, March 2026.
Abrupt cuts in external health aid are shown to destabilize multiple essential services simultaneously in fragile settings. Evidence from Nepal and Afghanistan reveals cascading disruption across family planning, nutrition, immunization, community‐based care, and disease surveillance.
Animesh Ghimire
wiley   +1 more source

International Network for Capacity Building for the Control of Emerging Viral Vector-Borne Zoonotic Diseases: Arbo-Zoonet

, 2009
Arboviruses are arthropod-borne viruses, which include West Nile fever virus (WNFV), a mosquito-borne virus, Rift Valley fever virus (RVFV), a mosquito-borne virus, and Crimean-Congo haemorrhagic fever virus (CCHFV), a tick-borne virus.
Paweska, J., Yin, H., Tordo, N., Unger, H., Fooks, A.R., Vatansever, Z., Estrada-Pena, A., Ahmed, J., Bouloy, M., Mirazimi, A., Seitzer, U., Moormann, R.J.M., Calistri, P., Chevalier, V., Drosten, C., Ergonul, O.   +15 more
core  

Unique Strain of Crimean–Congo Hemorrhagic Fever Virus, Mali

Emerging Infectious Diseases, 2014
To the Editor: Crimean-Congo hemorrhagic fever (CCHF) is an acute viral infection that causes mild to severe hemorrhagic fever characterized by petechiae, ecchymosis, disseminated intravascular coagulation, and multi-organ failure (1). The etiologic agent, CCHF virus (CCHFV; family Bunyaviridae, genus Nairovirus), is maintained in enzootic cycles ...
Marko Zivcec, Ousmane Maïga, Ashley Kelly, Friederike Feldmann, Nafomon Sogoba, Tom G. Schwan, Heinz Feldmann, David Safronetz   +7 more
openaire   +3 more sources

Crimean-Congo Hemorrhagic Fever Virus for Clinicians—Diagnosis, Clinical Management, and Therapeutics

Emerging Infectious Diseases
Crimean-Congo hemorrhagic fever virus (CCHFV) is the most geographically widespread tickborne viral infection worldwide and has a fatality rate of up to 62%.
M. Frank, Gretchen K. Weaver, Vanessa Raabe   +2 more
semanticscholar   +1 more source

Sex Differences in Response to Viral Vector Vaccines—Implications for Future Vaccine Design

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Vaccination represents one of the most impactful public health achievements, preventing 3.5 to 5 million deaths annually according to estimates of the World Health Organization. Yet, recent outbreaks of emerging and reemerging infectious diseases highlight the need for rapid and strategic vaccine development using vaccine platforms ...
Ilka Grewe, Tamara Zoran, Marylyn Martina Addo   +2 more
wiley   +1 more source

Differences in cynomolgus macaque populations used for infectious disease research

Animal Models and Experimental Medicine, Volume 9, Issue 2, Page 298-307, February 2026.
Cynomolgus macaques, a species of Old World primate native to southeastern and eastern Asia and the island of Mauritius, are one of the most important nonhuman primate models for infectious disease. Research into the population genetics of cynomolgus macaques has found significant differences between macaques native to different areas, particularly ...
Darcy Quist, Kimimuepigha Ebisine, Emma Kennedy, Stuart Dowall, Mike Dennis   +4 more
wiley   +1 more source