Results 1 to 10 of about 2,525 (164)

Geographical Variability Affects CCHFV Detection by RT–PCR: A Tool for In-Silico Evaluation of Molecular Assays [PDF]

Viruses, 2019
The Crimean−Congo hemorrhagic fever virus (CCHFV) is considered to be a major emerging infectious threat, according to the WHO R&D blueprint. A wide range of CCHFV molecular assays have been developed, employing varied primer/probe combinations.
Antonino Di Caro, Tatjana Avšič Zupanc, Concetta Castilletti   +2 more
exaly   +10 more sources

The Role of Nucleocapsid Protein (NP) in the Immunology of Crimean–Congo Hemorrhagic Fever Virus (CCHFV)

Viruses
Crimean–Congo hemorrhagic fever virus (CCHFV) is an orthonairovirus from the Bunyavirales order that is widely distributed geographically and causes severe or fatal infections in humans.
Mehmet Doymaz, Aysegul Pirinçal
exaly   +6 more sources

A CCHFV DNA vaccine protects against heterologous challenge and establishes GP38 as immunorelevant in mice [PDF]

npj Vaccines, 2021
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus that causes severe hemorrhagic fever disease in humans. Currently, no licensed CCHF vaccines exist, and the protective epitopes remain unclear.
John J. Suschak, Joseph W. Golden, Collin J. Fitzpatrick, Charles J. Shoemaker, Catherine V. Badger, Connie S. Schmaljohn, Aura R. Garrison   +6 more
doaj   +3 more sources

Fluorometric CCHFV OTU protease assay with potent inhibitors

Virus Genes, 2015
Crimean-Congo hemorrhagic fever virus (CCHFV) is a deadly virus that has been listed in the Category C as a potential bioterror agent. There are no specific therapies against CCHFV, which urges identification of potential therapeutic targets and development of CCHFV therapies.
Fatih Kocabas, Galip Servet Aslan, Kocabas Fatih   +2 more
exaly   +4 more sources

The low-density lipoprotein receptor and apolipoprotein E associated with CCHFV particles mediate CCHFV entry into cells

Nature Communications
The Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging pathogen of the Orthonairovirus genus that can cause severe and often lethal hemorrhagic diseases in humans. CCHFV has a broad tropism and can infect a variety of species and tissues. Here,
Maureen Ritter, Lola Canus, Anupriya Gautam, Thomas Vallet, Li Zhong, Alexandre Lalande, Bertrand Boson, Apoorv Gandhi, Sergueï Bodoirat, Julien Burlaud-Gaillard, Natalia Freitas, Philippe Roingeard, John N. Barr, Vincent Lotteau, Vincent Legros, Cyrille Mathieu, François-Loïc Cosset, Solène Denolly   +17 more
doaj   +6 more sources

Sheep and Cattle Are Not Susceptible to Experimental Inoculation with Hazara Orthonairovirus, a Tick-Borne Arbovirus Closely Related to CCHFV

Microorganisms, 2020
Hazara orthonairovirus (HAZV) is a tick-borne arbovirus closely related to Crimean–Congo hemorrhagic fever orthonairovirus (CCHFV). Whereas CCHFV is a biosafety level (BSL) 4 agent, HAZV is classified as BSL 2, as it is not known to cause any disease in ...
Christine Fast, Maryna Somova, Martin H Groschup   +2 more
exaly   +3 more sources

The PACS-2 protein and trafficking motifs in CCHFV Gn and Gc cytoplasmic domains govern CCHFV assembly

Emerging Microbes and Infections
The Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne bunyavirus that causes high mortality in humans. This enveloped virus harbors two surface glycoproteins (GP), Gn and Gc, that are released by processing of a glycoprotein precursor complex whose maturation takes place in the ER and is completed through the secretion pathway.
François-Loïc Cosset, Solene Lerolle, Vincent Legros   +2 more
exaly   +5 more sources

Serial expression of the truncated fragments of the nucleocapsid protein of CCHFV and identification of the epitope region

Virologica Sinica, 2010
The Crimean-congo hemorrhagic fever virus (CCHFV) is a geographically widespread fatal pathogen. Identification of the epitope regions of the virus is important for the diagnosis and epidemiological studies of CCHFV infections. In this study, expression vectors carrying series truncated fragments of the NP (nucleocapsid protein) gene from the S ...
Fei Deng, Hua-Lin Wang, Zhi-Hong Hu
exaly   +4 more sources

Discovery of baloxavir sodium as a novel anti-CCHFV inhibitor: Biological evaluation of in vitro and in vivo

Antiviral Research
Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic bunyavirus with a fatality rate of up to 40%. Currently, there are no licensed antiviral drugs for the treatment of CCHF; thus, the World Health Organization (WHO) listed the disease as a priority.
Liushuai Li
exaly   +3 more sources

Cellular immunity to nucleoproteins (NP) of Crimean-Congo hemorrhagic fever virus (CCHFV) and Hazara Virus (HAZV)

Medical Microbiology and Immunology
Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a globally significant vector-borne pathogen with no internationally-licensed preventative and therapeutic interventions. Hazara virus (HAZV), on the other hand, a related Orthonairovirus, has not been reported as a human pathogen.
Elif Karaaslan, Mehmet Doymaz, Karaaslan Elif   +2 more
exaly   +4 more sources