Results 1 to 10 of about 3,609 (205)

Geographical Variability Affects CCHFV Detection by RT–PCR: A Tool for In-Silico Evaluation of Molecular Assays [PDF]

Viruses, 2019
The Crimean−Congo hemorrhagic fever virus (CCHFV) is considered to be a major emerging infectious threat, according to the WHO R&D blueprint. A wide range of CCHFV molecular assays have been developed, employing varied primer/probe combinations.
Cesare Ernesto Maria Gruber, Barbara Bartolini, Concetta Castilletti   +2 more
exaly   +15 more sources

The Role of Nucleocapsid Protein (NP) in the Immunology of Crimean–Congo Hemorrhagic Fever Virus (CCHFV)

Viruses
Crimean–Congo hemorrhagic fever virus (CCHFV) is an orthonairovirus from the Bunyavirales order that is widely distributed geographically and causes severe or fatal infections in humans.
Aysegul Pirinçal, Mehmet Z Doymaz
exaly   +7 more sources

The low-density lipoprotein receptor and apolipoprotein E associated with CCHFV particles mediate CCHFV entry into cells [PDF]

Nature Communications
The Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging pathogen of the Orthonairovirus genus that can cause severe and often lethal hemorrhagic diseases in humans. CCHFV has a broad tropism and can infect a variety of species and tissues. Here,
Maureen Ritter, Lola Canus, Anupriya Gautam, Thomas Vallet, Li Zhong, Alexandre Lalande, Bertrand Boson, Apoorv Gandhi, Sergueï Bodoirat, Julien Burlaud-Gaillard, Natalia Freitas, Philippe Roingeard, John N. Barr, Vincent Lotteau, Vincent Legros, Cyrille Mathieu, François-Loïc Cosset, Solène Denolly   +17 more
doaj   +7 more sources

CCHFV Seroprevalence among Hunter-Gatherers, Northeastern Democratic Republic of the Congo [PDF]

Emerging Infectious Diseases
We evaluated human Crimean-Congo hemorrhagic fever virus (CCHFV) seroprevalence in hunter-gatherer populations of northeastern Democratic Republic of the Congo. We tested blood from 300 participants for CCHFV antibodies; 4% were CCHFV-positive.
Dacquin M. Kasumba, Samuel M. Shamamba, Ange Y. Mubiala, Bobo N. Bazola, Amanda C. Horton, Charles Ndawula, Jean-Jacques Muyembe-Tamfum, Jean-Christophe Sabue Mulangu   +7 more
doaj   +3 more sources

A CCHFV DNA vaccine protects against heterologous challenge and establishes GP38 as immunorelevant in mice [PDF]

npj Vaccines, 2021
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus that causes severe hemorrhagic fever disease in humans. Currently, no licensed CCHF vaccines exist, and the protective epitopes remain unclear.
John J. Suschak, Joseph W. Golden, Collin J. Fitzpatrick, Charles J. Shoemaker, Catherine V. Badger, Connie S. Schmaljohn, Aura R. Garrison   +6 more
doaj   +3 more sources

Sheep and goats as indicator animals for the circulation of CCHFV in the environment [PDF]

Experimental and Applied Acarology, 2015
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus, which causes a serious illness with case-fatality rates of up to 80% in humans. CCHFV is endemic in many countries of Africa, Asia and Southeastern Europe. Next to the countries with endemic areas, the distribution of CCHFV is unknown in Southeastern Europe. As the antibody prevalence
Schuster, Isolde, Mertens, Marc, Mrenoshki, Slavcho, Staubach, Christoph, Mertens, Corinna, Brüning, Franziska, Wernike, Kerstin, Hechinger, Silke, Berxholi, Kristaq, Mitrov, Dine, Groschup, Martin H.   +10 more
openaire   +4 more sources

Host Community Traits Driving Crimean-Congo Hemorrhagic Fever Virus Maintenance in Iberian Ecosystems. [PDF]

Transbound Emerg Dis
Crimean‐Congo hemorrhagic fever (CCHF) is a tick‐borne zoonosis of significant public health concern, maintained in complex multihost systems shaped by ecological, climatic, and anthropogenic drivers. In the Iberian Peninsula, changing land‐use patterns and biodiversity loss may be reshaping host communities in ways that alter local transmission ...
Xavier P, Perelló A, Luque-Castro V, Relimpio D, Barroso P, Almeida V, de la Fuente J, Balseiro A, Ruiz-Fons F, Gortázar C.   +9 more
europepmc   +2 more sources

Sheep and Cattle Are Not Susceptible to Experimental Inoculation with Hazara Orthonairovirus, a Tick-Borne Arbovirus Closely Related to CCHFV

Microorganisms, 2020
Hazara orthonairovirus (HAZV) is a tick-borne arbovirus closely related to Crimean–Congo hemorrhagic fever orthonairovirus (CCHFV). Whereas CCHFV is a biosafety level (BSL) 4 agent, HAZV is classified as BSL 2, as it is not known to cause any disease in ...
Christine Fast, Maryna Somova, Ali Mirazimi   +2 more
exaly   +3 more sources

Widespread circulation of Crimean-Congo haemorrhagic fever virus in ticks, Corsica (France), 2024 [PDF]

One Health
Crimean-Congo Haemorrhagic Fever is a severe tick-borne viral disease with a high fatality rate. This study aimed to advance the understanding of CCHF virus (CCHFV) in terms of geographical spread and genotypic characterization by investigating its ...
Morena Gasparine, Armand Namekong Fokeng, Shirley Masse, Eva Lopez, Remi Charrel, Xavier de Lamballerie, Alessandra Falchi   +6 more
doaj   +2 more sources

IDENTIFICATION OF AN IMPORTANT FACTOR INVOLVED IN CCHFV INFECTION

, 2023
Despite intensive research, much of the molecular pathogenesis of CCHFV is still unknown. Genome-wide screening methods (particularly CRISPR/Cas9-based screens and insertional mutagenesis in haploid cell systems) have facilitated and accelerated the identification and characterization of host genes involved in infectious diseases.
Vanessa Monteil, Matheus Dyczynski, S. C. Wright, M. J. Kellner, Sofia Appelberg, S. W. Platzer, Hyesoo Kwon, Ioannis Pittarokoilis, Mattia Mirandola, Georg Michlits, Sthepanie Devignot, Elizabeth Elder, Samir Abdurahman, Sandor Bereczky, Binnur Bagci, Sonia Youhanna, V. M. Lauschke, Cristiano Salata, Nazif Elaldi, Friedemann Weber, Nuria Montserrat, Moritz Horn, J. M. Penninger, Ali Mirazimi   +23 more
openaire   +2 more sources