Results 1 to 10 of about 3,945 (173)

Geographical Variability Affects CCHFV Detection by RT–PCR: A Tool for In-Silico Evaluation of Molecular Assays [PDF]

Viruses, 2019
The Crimean−Congo hemorrhagic fever virus (CCHFV) is considered to be a major emerging infectious threat, according to the WHO R&D blueprint. A wide range of CCHFV molecular assays have been developed, employing varied primer/probe combinations.
Antonino di Caro, Tatjana Avšič Zupanc, Concetta Castilletti   +2 more
exaly   +5 more sources

The Role of Nucleocapsid Protein (NP) in the Immunology of Crimean–Congo Hemorrhagic Fever Virus (CCHFV)

Viruses
Crimean–Congo hemorrhagic fever virus (CCHFV) is an orthonairovirus from the Bunyavirales order that is widely distributed geographically and causes severe or fatal infections in humans.
Mehmet Doymaz, Aysegul Pirinçal
exaly   +4 more sources

Sheep and Cattle Are Not Susceptible to Experimental Inoculation with Hazara Orthonairovirus, a Tick-Borne Arbovirus Closely Related to CCHFV

Microorganisms, 2020
Hazara orthonairovirus (HAZV) is a tick-borne arbovirus closely related to Crimean–Congo hemorrhagic fever orthonairovirus (CCHFV). Whereas CCHFV is a biosafety level (BSL) 4 agent, HAZV is classified as BSL 2, as it is not known to cause any disease in ...
Christine Fast, Maryna Somova, Martin H Groschup   +2 more
exaly   +3 more sources

Serosurvey of Crimean-Congo Hemorrhagic Fever Virus in dromedary camels (Camelus dromedarius) in Egypt [PDF]

Frontiers in Veterinary Science
Crimean-Congo hemorrhagic fever virus (CCHFV) is recognized as one of the most severe zoonotic viruses, marked by gastrointestinal disturbances and hemorrhagic symptoms in its more severe forms.
Ehab Kotb Elmahallawy, Ehab Kotb Elmahallawy, Mohamed El-Zayat, Mario Frías, Mario Frías, Mario Frías, Wejdan Oudah Albalawi, Samar A. Eissa, Manal F. El-Khadragy, Mustafa Shukry, Safaa Gamal Amer, Ignacio García-Bocanegra, Ignacio García-Bocanegra   +12 more
doaj   +2 more sources

Convalescent human plasma candidate reference materials protect against Crimean-Congo haemorrhagic fever virus (CCHFV) challenge in an A129 mouse model

Virus Research
Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is spread by infected ticks or direct contact with blood, tissues and fluids from infected patients or livestock.
Victoria Graham, Sarah Kempster, Francisco J Salguero   +2 more
exaly   +3 more sources

CCHFV Seroprevalence among Hunter-Gatherers, Northeastern Democratic Republic of the Congo [PDF]

Emerging Infectious Diseases
We evaluated human Crimean-Congo hemorrhagic fever virus (CCHFV) seroprevalence in hunter-gatherer populations of northeastern Democratic Republic of the Congo. We tested blood from 300 participants for CCHFV antibodies; 4% were CCHFV-positive.
Dacquin M. Kasumba, Samuel M. Shamamba, Ange Y. Mubiala, Bobo N. Bazola, Amanda C. Horton, Charles Ndawula, Jean-Jacques Muyembe-Tamfum, Jean-Christophe Sabue Mulangu   +7 more
doaj   +2 more sources

The Crimean-Congo haemorrhagic fever virus hijacks the liver lipid metabolic pathway for virion production [PDF]

Emerging Microbes and Infections
The Crimean-Congo Haemorrhagic Fever Virus (CCHFV), a tri-segmented negative-strand virus that belongs to the Orthonairovirus genus, is highly pathogenic in humans but not in other host species.
Anupriya Gautam, Li Zhong, Eva Ogire, Sergueï Bodoirat, Ilary Riedmiller, Willem J. Sander, Bertrand Boson, Apoorv Gandhi, Julien Burlaud-Gaillard, Fouzia Amirache, Vincent Legros, Philippe Roingeard, Vincent Lotteau, Cyrille Mathieu, François-Loïc Cosset, Solène Denolly   +15 more
doaj   +2 more sources

Development of anti-Crimean-Congo hemorrhagic fever virus Gc and NP-specific ELISA for detection of antibodies in domestic animal sera

Frontiers in Veterinary Science, 2022
Crimean-Congo hemorrhagic fever (CCHF) is a priority emerging disease. CCHF, caused by the CCHF virus (CCHFV), can lead to hemorrhagic fever in humans with severe cases often having fatal outcomes. CCHFV is maintained within a tick-vertebrate-tick cycle,
Sandra Belij-Rammerstorfer, Georgina Limon, Emmanuel A. Maze, Kayleigh Hannant, Ellen Hughes, Simona R. Tchakarova, Tsviatko Alexandrov, Blandina T. Mmbaga, Blandina T. Mmbaga, Brian Willett, George Booth, Nicholas A. Lyons, Natalie Baker, Kelly M. Thomas, Daniel Wright, Jack Saunders, Clare Browning, Ginette Wilsden, Miles Carroll, Roger Hewson, Roger Hewson, Bryan Charleston, Teresa Lambe, Anna B. Ludi   +23 more
doaj   +1 more source

Differential Cell Line Susceptibility to Crimean-Congo Hemorrhagic Fever Virus

Frontiers in Cellular and Infection Microbiology, 2021
Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne viral disease of global concerns due to the increasing incidence and lack of effective treatments.
Shiyu Dai, Qiaoli Wu, Xiaoli Wu, Cheng Peng, Jia Liu, Shuang Tang, Tao Zhang, Fei Deng, Shu Shen   +8 more
doaj   +1 more source

A CCHFV DNA vaccine protects against heterologous challenge and establishes GP38 as immunorelevant in mice

npj Vaccines, 2021
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus that causes severe hemorrhagic fever disease in humans. Currently, no licensed CCHF vaccines exist, and the protective epitopes remain unclear.
John J. Suschak, Joseph W. Golden, Collin J. Fitzpatrick, Charles J. Shoemaker, Catherine V. Badger, Connie S. Schmaljohn, Aura R. Garrison   +6 more
doaj   +1 more source