Results 1 to 10 of about 5,642 (225)

The low-density lipoprotein receptor and apolipoprotein E associated with CCHFV particles mediate CCHFV entry into cells

Nature Communications
The Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging pathogen of the Orthonairovirus genus that can cause severe and often lethal hemorrhagic diseases in humans. CCHFV has a broad tropism and can infect a variety of species and tissues. Here,
Maureen Ritter, Lola Canus, Anupriya Gautam, Thomas Vallet, Li Zhong, Alexandre Lalande, Bertrand Boson, Apoorv Gandhi, Sergueï Bodoirat, Julien Burlaud-Gaillard, Natalia Freitas, Philippe Roingeard, John N. Barr, Vincent Lotteau, Vincent Legros, Cyrille Mathieu, François-Loïc Cosset, Solène Denolly   +17 more
doaj   +8 more sources

A CCHFV DNA vaccine protects against heterologous challenge and establishes GP38 as immunorelevant in mice [PDF]

npj Vaccines, 2021
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus that causes severe hemorrhagic fever disease in humans. Currently, no licensed CCHF vaccines exist, and the protective epitopes remain unclear.
John J. Suschak, Joseph W. Golden, Collin J. Fitzpatrick, Charles J. Shoemaker, Catherine V. Badger, Connie S. Schmaljohn, Aura R. Garrison   +6 more
doaj   +6 more sources

Geographical Variability Affects CCHFV Detection by RT–PCR: A Tool for In-Silico Evaluation of Molecular Assays [PDF]

Viruses, 2019
The Crimean−Congo hemorrhagic fever virus (CCHFV) is considered to be a major emerging infectious threat, according to the WHO R&D blueprint. A wide range of CCHFV molecular assays have been developed, employing varied primer/probe combinations.
Cesare E. M. Gruber, Barbara Bartolini, Concetta Castilletti, Ali Mirazimi, Roger Hewson, Iva Christova, Tatjana Avšič, Roland Grunow, Anna Papa, María P. Sánchez-Seco, Marion Koopmans, Giuseppe Ippolito, Maria R. Capobianchi, Chantal B. E. M. Reusken, Antonino Di Caro   +14 more
doaj   +12 more sources

The Role of Nucleocapsid Protein (NP) in the Immunology of Crimean–Congo Hemorrhagic Fever Virus (CCHFV)

Viruses
Crimean–Congo hemorrhagic fever virus (CCHFV) is an orthonairovirus from the Bunyavirales order that is widely distributed geographically and causes severe or fatal infections in humans.
Aysegul Pirincal, Mehmet Z. Doymaz
doaj   +6 more sources

CCHFV Seroprevalence among Hunter-Gatherers, Northeastern Democratic Republic of the Congo [PDF]

Emerging Infectious Diseases
We evaluated human Crimean-Congo hemorrhagic fever virus (CCHFV) seroprevalence in hunter-gatherer populations of northeastern Democratic Republic of the Congo. We tested blood from 300 participants for CCHFV antibodies; 4% were CCHFV-positive.
Dacquin M. Kasumba, Samuel M. Shamamba, Ange Y. Mubiala, Bobo N. Bazola, Amanda C. Horton, Charles Ndawula, Jean-Jacques Muyembe-Tamfum, Jean-Christophe Sabue Mulangu   +7 more
doaj   +3 more sources

Sheep and Cattle Are Not Susceptible to Experimental Inoculation with Hazara Orthonairovirus, a Tick-Borne Arbovirus Closely Related to CCHFV

Microorganisms, 2020
Hazara orthonairovirus (HAZV) is a tick-borne arbovirus closely related to Crimean–Congo hemorrhagic fever orthonairovirus (CCHFV). Whereas CCHFV is a biosafety level (BSL) 4 agent, HAZV is classified as BSL 2, as it is not known to cause any disease in ...
Julia Hartlaub, Felicitas von Arnim, Christine Fast, Maryna Somova, Ali Mirazimi, Martin H. Groschup, Markus Keller   +6 more
doaj   +4 more sources

Discovery of baloxavir sodium as a novel anti-CCHFV inhibitor: Biological evaluation of in vitro and in vivo

Antiviral Research
Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic bunyavirus with a fatality rate of up to 40%. Currently, there are no licensed antiviral drugs for the treatment of CCHF; thus, the World Health Organization (WHO) listed the disease as
Yiwu Zhou
exaly   +4 more sources

Transmission Dynamics of Crimean–Congo Haemorrhagic Fever Virus (CCHFV): Evidence of Circulation in Humans, Livestock, and Rodents in Diverse Ecologies in Kenya

Viruses, 2023
Crimean–Congo haemorrhagic fever virus (CCHFV) is the causative agent of CCHF, a fatal viral haemorrhagic fever disease in humans. The maintenance of CCHFV in the ecosystem remains poorly understood.
Dorcus C. A. Omoga, David P. Tchouassi, Marietjie Venter, Edwin O. Ogola, Josephine Osalla, Anne Kopp, Inga Slothouwer, Baldwyn Torto, Sandra Junglen, Rosemary Sang   +9 more
doaj   +2 more sources

Direct and Indirect Role of Migratory Birds in Spreading CCHFV and WNV: A Multidisciplinary Study on Three Stop-Over Islands in Italy

Pathogens, 2022
The annual movements of migratory birds can contribute to the spread of African ticks and tick-borne pathogens of potential public health concern across Europe.
Elisa Mancuso, L Toma, Ilaria Pascucci
exaly   +2 more sources

Field vaccination against CCHFV and Hyalomma tick infestation reduces multiple tick-borne infections in sheep. [PDF]

NPJ Vaccines
Tick-borne pathogens (TBPs) are expanding globally, with their impact on public health expected to rise due to climate change. Immunizing livestock offers a cost-effective alternative or adjunct to human vaccination.
Mhamadi M, Babuadze GG, Badji A, Echanove J, Gaye A, Ndiaye EH, Ndiaye O, Ndiaye M, Dieng I, Xiii A, Mhamadi M, Touré CT, Fall M, Faye O, Fausther-Bovendo H, Faye O, Sall AA, Kobinger G.   +17 more
europepmc   +2 more sources