Results 21 to 30 of about 3,609 (205)
Immunological Analysis of a CCHFV mRNA Vaccine Candidate in Mouse Models [PDF]
Vaccines, 2019 Development of new vaccine platforms against viral diseases is considered urgent. In recent years, mRNA constructs have attracted great interest in this field due to unique advantages over conventional gene transfer platforms. In the present study, we developed a new naked conventional mRNA vaccine expressing the non-optimized small (S) segment of the ...
Touraj Aligholipour Farzani +5 more
openaire +5 more sources
CCHFV vaccine development, current challenges, limitations, and future directions
Frontiers in Immunology, 2023 Crimean-Congo hemorrhagic fever (CCHF) is the most prevalent tick-borne viral disease affecting humans. The disease is life-threatening in many regions of the developing world, including Africa, Asia, the Middle East, and Southern Europe. In line with the rapidly increasing disease prevalence, various vaccine strategies are under development. Despite a
Büşra Ahata +2 more
openaire +3 more sources
International Journal of Infectious Diseases, 2023 Intro: Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV), is the causative agent of Crimean-Congo hemorrhagic fever (CCHF). Occurrence of the virus coincides with the distribution of its primary vector and reservoir, Hyalomma ticks.
A. Mirazimi
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 Crimean-Congo hemorrhagic fever virus (CCHFV) can cause severe hemorrhagic fever in humans and is mainly transmitted by ticks. There is no effective vaccine for Crimean-Congo hemorrhagic fever (CCHF) at present.
Yong-Liang Hu +15 more
doaj +1 more source
CCHFV-related viruses (Family Bunyaviridae).
, 2022 CCHFV-related viruses (Family Bunyaviridae).
Greg Smith (343139) +5 more
core +1 more source
Mutational analysis of catalytic site domain of CCHFV L RNA segment
Journal of Molecular Modeling, 2023 Crimean-Congo haemorrhagic fever virus (CCHFV) has tripartite RNA genome and is endemic in various countries of Asia, Africa and Europe.The present study is focused on mutation profiling of CCHFV L segment and phylogenetic clustering of protein dataset into six CCHFV genotypes.Phylogenetic tree rooted with NCBI reference sequence (YP_325663.1 ...
Neha Kaushal, Manoj Baranwal
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Induced protection from a CCHFV-M DNA vaccine requires CD8+ T cells
Virus Research, 2023 Crimean-Congo hemorrhagic fever (CCHF) is a World Health Organization prioritized disease because its broad distribution and severity of disease make it a global health threat. Despite advancements in preclinical vaccine development for CCHF virus (CCHFV), including multiple platforms targeting multiple antigens, a clear definition of the adaptive ...
Joseph W. Golden +6 more
openaire +3 more sources
CCHF Viral RNA, anti-CCHFV IgM and anti-CCHFV IgG kinetics of CCHFV cases.
, 2021 (A) CCHF viral RNA amongst fatal and survivors (B) CCHF viral RNA amongst individual survivors at different time points (C) Anti-CCHFV-IgM antibodies amongst individual survivors at different time points and fatal cases (D) Anti-CCHFV-IgG antibodies ...
Himanshu Kaushal (558851) +13 more
core +1 more source
Immunocompetent mouse model for Crimean-Congo hemorrhagic fever virus
eLife, 2021 Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne febrile illness with wide geographic distribution. CCHF is caused by infection with the Crimean-Congo hemorrhagic fever virus (CCHFV) and case fatality rates can be as high as 30%.
David W Hawman +7 more
doaj +1 more source
Clade-representing CCHFV sequences.
, 2022 Clade-representing CCHFV sequences.
Greg Smith (343139) +5 more
core +1 more source