Results 21 to 30 of about 2,525 (164)

Crimean-Congo Hemorrhagic Fever Virus (CCHFV): A Silent but Widespread Threat [PDF]

Current Tropical Medicine Reports, 2021
Abstract Purpose of Review This review is aimed at highlighting recent research and articles on the complicated relationship between virus, vector, and host and how biosurveillance at each level informs disease spread and risk.
Paul A. Kuehnert, Christopher P. Stefan, Catherine V. Badger, Keersten M. Ricks   +3 more
openaire   +2 more sources

Development of anti-Crimean-Congo hemorrhagic fever virus Gc and NP-specific ELISA for detection of antibodies in domestic animal sera

Frontiers in Veterinary Science, 2022
Crimean-Congo hemorrhagic fever (CCHF) is a priority emerging disease. CCHF, caused by the CCHF virus (CCHFV), can lead to hemorrhagic fever in humans with severe cases often having fatal outcomes. CCHFV is maintained within a tick-vertebrate-tick cycle,
Sandra Belij-Rammerstorfer, Georgina Limon, Emmanuel A. Maze, Kayleigh Hannant, Ellen Hughes, Simona R. Tchakarova, Tsviatko Alexandrov, Blandina T. Mmbaga, Blandina T. Mmbaga, Brian Willett, George Booth, Nicholas A. Lyons, Natalie Baker, Kelly M. Thomas, Daniel Wright, Jack Saunders, Clare Browning, Ginette Wilsden, Miles Carroll, Roger Hewson, Roger Hewson, Bryan Charleston, Teresa Lambe, Anna B. Ludi   +23 more
doaj   +1 more source

Differential Cell Line Susceptibility to Crimean-Congo Hemorrhagic Fever Virus

Frontiers in Cellular and Infection Microbiology, 2021
Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne viral disease of global concerns due to the increasing incidence and lack of effective treatments.
Shiyu Dai, Qiaoli Wu, Xiaoli Wu, Cheng Peng, Jia Liu, Shuang Tang, Tao Zhang, Fei Deng, Shu Shen   +8 more
doaj   +1 more source

GP38 as a vaccine target for Crimean-Congo hemorrhagic fever virus

npj Vaccines, 2023
Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a tick-borne virus that causes severe hemorrhagic disease in humans. There is a great need for effective vaccines and therapeutics against CCHFV for humans, as none are currently internationally approved ...
Gabrielle Scher, Dennis A. Bente, Megan C. Mears, Maria N. B. Cajimat, Matthias J. Schnell   +4 more
doaj   +1 more source

Purification of Crimean–Congo hemorrhagic fever virus nucleoprotein and its utility for serological diagnosis

Scientific Reports, 2021
Crimean–Congo hemorrhagic fever virus (CCHFV) causes a zoonotic disease, Crimean–Congo hemorrhagic fever (CCHF) endemic in Africa, Asia, the Middle East, and Southeastern Europe.
Boniface Pongombo Lombe, Hiroko Miyamoto, Takeshi Saito, Reiko Yoshida, Rashid Manzoor, Masahiro Kajihara, Masayuki Shimojima, Shuetsu Fukushi, Shigeru Morikawa, Tomoki Yoshikawa, Takeshi Kurosu, Masayuki Saijo, Qing Tang, Justin Masumu, David Hawman, Heinz Feldmann, Ayato Takada   +16 more
doaj   +1 more source

Crimean–Congo Hemorrhagic Fever Virus Survey in Humans, Ticks, and Livestock in Agnam (Northeastern Senegal) from February 2021 to March 2022

Tropical Medicine and Infectious Disease, 2022
Crimean–Congo hemorrhagic fever virus (CCHFV) is widespread in Asia, Europe, and Africa. In Senegal, sporadic cases of CCHFV have been reported since 1960.
Moufid Mhamadi, Aminata Badji, Idrissa Dieng, Alioune Gaye, El Hadji Ndiaye, Mignane Ndiaye, Moundhir Mhamadi, Cheikh Talibouya Touré, Mouhamed Rassoul Mbaye, Mamadou Aliou Barry, Oumar Ndiaye, Babacar Faye, Fatimata Amadou Ba, Boly Diop, Mamadou Ndiaye, Mathioro Fall, Samba Niang Sagne, Gamou Fall, Cheikh Loucoubar, Hugues Fausther-Bovendo, Amadou Alpha Sall, Gary Kobinger, Ousmane Faye, Mawlouth Diallo, Oumar Faye   +24 more
doaj   +1 more source

Immunological Analysis of a CCHFV mRNA Vaccine Candidate in Mouse Models [PDF]

Vaccines, 2019
Development of new vaccine platforms against viral diseases is considered urgent. In recent years, mRNA constructs have attracted great interest in this field due to unique advantages over conventional gene transfer platforms. In the present study, we developed a new naked conventional mRNA vaccine expressing the non-optimized small (S) segment of the ...
Touraj Aligholipour Farzani, Katalin Földes, Koray Ergünay, Hakan Gurdal, Aliye Bastug, Aykut Ozkul   +5 more
openaire   +5 more sources

NUCLEOSIDE-MODIFIED MRNA VACCINES PROTECT IFNAR -/- MICE AGAINST CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS INFECTION

International Journal of Infectious Diseases, 2023
Intro: Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV), is the causative agent of Crimean-Congo hemorrhagic fever (CCHF). Occurrence of the virus coincides with the distribution of its primary vector and reservoir, Hyalomma ticks.
A. Mirazimi
doaj   +1 more source

CCHFV vaccine development, current challenges, limitations, and future directions

Frontiers in Immunology, 2023
Crimean-Congo hemorrhagic fever (CCHF) is the most prevalent tick-borne viral disease affecting humans. The disease is life-threatening in many regions of the developing world, including Africa, Asia, the Middle East, and Southern Europe. In line with the rapidly increasing disease prevalence, various vaccine strategies are under development. Despite a
Büşra Ahata, Büşra Ahata, Günseli Bayram Akçapınar   +2 more
openaire   +3 more sources

Construction and evaluation of DNA vaccine encoding Crimean Congo hemorrhagic fever virus nucleocapsid protein, glycoprotein N-terminal and C-terminal fused with LAMP1

Frontiers in Cellular and Infection Microbiology, 2023
Crimean-Congo hemorrhagic fever virus (CCHFV) can cause severe hemorrhagic fever in humans and is mainly transmitted by ticks. There is no effective vaccine for Crimean-Congo hemorrhagic fever (CCHF) at present.
Yong-Liang Hu, Yong-Liang Hu, Lian-Qing Zhang, Lian-Qing Zhang, Xiao-Qian Liu, Xiao-Qian Liu, Wei Ye, Yue-Xi Zhao, Yue-Xi Zhao, Liang Zhang, Zun-Xian Qiang, Lin-Xuan Zhang, Ying-Feng Lei, Dong-Bo Jiang, Lin-Feng Cheng, Fang-Lin Zhang   +15 more
doaj   +1 more source