Results 11 to 20 of about 5,642 (225)
Immunological Analysis of a CCHFV mRNA Vaccine Candidate in Mouse Models [PDF]
Vaccines, 2019 Development of new vaccine platforms against viral diseases is considered urgent. In recent years, mRNA constructs have attracted great interest in this field due to unique advantages over conventional gene transfer platforms.
Touraj Aligholipour Farzani +2 more
exaly +7 more sources
Experimental Challenge of Sheep and Cattle with Dugbe Orthonairovirus, a Neglected African Arbovirus Distantly Related to CCHFV [PDF]
Viruses, 2021 Dugbe orthonairovirus (DUGV) is a tick-borne arbovirus within the order Bunyavirales. DUGV was first isolated in Nigeria, but virus isolations in ten further African countries indicate that DUGV is widespread throughout Africa.
Christine Fast +2 more
exaly +5 more sources
PLoS Neglected Tropical Diseases, 2018 As the most widespread tick-borne arbovirus causing infections in numerous countries in Asia, Africa and Europe, Crimean-Congo Hemorrhagic Fever Virus (CCHFV, family Nairoviridae) was included in the WHO priority list of emerging pathogens needing urgent
Petra Emmerich +2 more
exaly +6 more sources
CCHFV vaccine development, current challenges, limitations, and future directions
Frontiers in Immunology, 2023 Crimean-Congo hemorrhagic fever (CCHF) is the most prevalent tick-borne viral disease affecting humans. The disease is life-threatening in many regions of the developing world, including Africa, Asia, the Middle East, and Southern Europe.
Büşra Ahata, Günseli Bayram Akcapinar
semanticscholar +4 more sources
Induced protection from a CCHFV-M DNA vaccine requires CD8+ T cells
Virus Research, 2023 Highlights • An M-segment based DNA vaccine, CCHFV-MAfg09, protects mice from lethal challenge.• CD8+ T-cell responses are necessary and sufficient for protection in CCHFV-MAfg09 vaccinated mice.• The humoral response is dispensable for the protection ...
J. W. Golden +6 more
semanticscholar +4 more sources
Favipiravir and Ribavirin protect immunocompetent mice from lethal CCHFV infection.
Antiviral Research, 2023 Crimean-Congo hemorrhagic fever virus (CCHFV) causes Crimean-Congo hemorrhagic fever (CCHF) in humans with high morbidity and mortality. Currently, there is neither an approved antiviral drug nor a vaccine against CCHFV.
Thomas Tipih +7 more
semanticscholar +3 more sources
Crimean-Congo Hemorrhagic Fever Virus (CCHFV): A Silent but Widespread Threat [PDF]
Current Tropical Medicine Reports, 2021 Purpose of Review This review is aimed at highlighting recent research and articles on the complicated relationship between virus, vector, and host and how biosurveillance at each level informs disease spread and risk.
P. Kuehnert +3 more
semanticscholar +3 more sources
Mutational analysis of catalytic site domain of CCHFV L RNA segment
Journal of Molecular Modeling, 2023 Crimean-Congo haemorrhagic fever virus (CCHFV) has tripartite RNA genome and is endemic in various countries of Asia, Africa and Europe. The present study is focused on mutation profiling of CCHFV L segment and phylogenetic clustering of protein dataset ...
N. Kaushal, M. Baranwal
semanticscholar +3 more sources
Emerging Microbes & InfectionsThe Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne bunyavirus that causes high mortality in humans. This enveloped virus harbors two surface glycoproteins (GP), Gn and Gc, that are released by processing of a glycoprotein precursor complex
Anupriya Gautam +11 more
semanticscholar +5 more sources
The first clinical case due to AP92 like strain of Crimean-Congo Hemorrhagic Fever virus and a field survey [PDF]
BMC Infectious Diseases, 2009 Background Crimean-Congo Hemorrhagic Fever (CCHF) is a fatal infection, but no clinical case due to AP92 strain was reported. We described the first clinical case due to AP92 like CCHFV.
Midilli Kenan +8 more
doaj +3 more sources