Results 91 to 100 of about 5,089,545 (386)

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Somatic symptoms and insomnia among bereaved parents and siblings eight years after the Utøya terror attack

European Journal of Psychotraumatology
Background: Levels of prolonged grief symptoms (PGS) and post-traumatic stress symptoms (PTSS) can be high, many years following bereavement after terror, but knowledge concerning somatic health is scarce.
Erik-Edwin Leonard Nordström, Riittakerttu Kaltiala, Pål Kristensen, Jens C. Thimm   +3 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

The digitalization and public crisis responses of small and medium enterprises: Implications from a COVID-19 survey

Frontiers of Business Research in China, 2020
The COVID-19 outbreak is a global crisis that has placed small and medium enterprises (SMEs) under huge pressure to survive, requiring them to respond effectively to the crisis.
Hai Guo, Zhuen Yang, Ran Huang, Anqi Guo
semanticscholar   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Sexual orientation differences in treatment expectation, alliance, and outcome among patients at risk for suicide in a public psychiatric hospital

BMC Psychiatry, 2017
Background Sexual minority (SM) individuals (gay, lesbian, bisexual, or otherwise nonheterosexual) are at increased risk for mental disorders and suicide and adequate mental healthcare may be life-saving.
Martin Plöderl, Sabine Kunrath, Robert J. Cramer, Jen Wang, Larissa Hauer, Clemens Fartacek   +5 more
doaj   +1 more source

Una crisis en la crisis. A Crisis in the Crisis

Metafísica y persona, 2017
La crisis actual se interpreta habitualmente de manera reduccionista: bien como crisis económica, bien como efecto de la más amplia crisis de valores, bien como causa de esa desorientación más general… Pero casi siempre con un modo de conocer y de razonar unidireccionales y abstractos.
openaire   +2 more sources

The prescription opioid and heroin crisis: a public health approach to an epidemic of addiction.

Annual Review of Public Health, 2015
Public health authorities have described, with growing alarm, an unprecedented increase in morbidity and mortality associated with use of opioid pain relievers (OPRs).
Andrew J. Kolodny, D. Courtwright, Catherine S. Hwang, P. Kreiner, John L. Eadie, Thomas W. Clark, G. Alexander   +6 more
semanticscholar   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Sanctions and Embargoes as a Crisis Response Instrument in the Context of the Ukrainian Crisis

Communications, 2015
The paper analyzes the importance of sanctions and embargoes as a tool used by organizations of international crisis management to resolve large-scale crisis events in a peaceful way.
Veronika Orieskova, Jan Havko
doaj   +1 more source