Results 171 to 180 of about 5,089,545 (386)
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Bitcoin as a new stage financial liberalization
Контуры глобальных трансформаций: политика, экономика, право, 2016 The high volatility in financial markets in developing and developed countries increases investors interest in new forms of investment assets. One of these forms are cryptocurrency and the most common of them -Bitcoin. The article examines the attractive
Anna Shestopalova
doaj
Book Review: VI. Miscellaneous: Christianity and the Social Crisis [PDF]
, 1907 J. L. Kesler
openalex +1 more source
revista PH, 2013 "...Por tanto, mi axioma será justamente ese, que el patrimonio “se dice” (como el “ser” aristotélico) de muchas maneras, una de ellas es la económica. ¿Es esta faceta económica la más relevante? Esta es la cuestión, maximizada por los tiempos que corren. Pero, en mi opinión, tal emergencia histórica carece de sentido.
openaire +3 more sources
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Book Review: II. Philosophy and Religion: Modern Thought and the Crisis in Belief [PDF]
, 1910 W. O. Carver
openalex +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source