Results 171 to 180 of about 4,533,202 (342)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

From 'aidland' to 'homeland': what the lived experiences of Ukrainian crisis leaders indicate about humanitarian response. [PDF]

Disasters
Kelly M, Pardy M, Downing DP.
europepmc   +1 more source

Towards a Lasting Peace in Nepal: The Constitutional Issues [PDF]

, 2005
International Crisis Group
core  

A comprehensive approach to the euro-area debt crisis [PDF]

In this Policy Brief Zsolt Darvas, André Sapir and Jean Pisani-Ferry, propose a comprehensive solution to the current European crisis based in three pillars: a plan to restore banking sector soundness, a resolution of sovereign debt crisis including a ...
André Sapir, Jean Pisani-Ferry, Zsolt Darvas   +2 more
core   +1 more source

Responding to the public health consequences of the Ukraine crisis: an opportunity for global health diplomacy [PDF]

, 2015
Tim K. Mackey, Steffanie A. Strathdee
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The internal democracy of the crisis parties in Western Europe: a quantitative analysis of the role of digitalization, ideology and populism. [PDF]

Open Res Eur
Bronet J, Borge R.
europepmc   +1 more source

Nepal: Peace Postponed [PDF]

, 2007
International Crisis Group
core  

The NHS crisis is not an equal crisis

BMJ, 2023
Williams, Simon, Pagel, Christina
openaire   +3 more sources

Did the Absence of a Central Bank Backstop in the Sovereign Bond Markets Exacerbate Spillovers During the Euro-Area Crisis?

, 2020
Heather D. Gibson, Stephen G. Hall, Deborah Gefang, Pavlos Petroulas, George S. Tavlas   +4 more
openalex   +1 more source