Results 91 to 100 of about 3,275,688 (215)

Central Asia: Crisis Conditions in Three States

, 2000
This is an ICG Asia Report titled Central Asia: Crisis Conditions in Three States: It analyzes the political and social crises facing three Central Asian countries, examining the factors contributing to instability, such as authoritarian governance ...
International Crisis Group
core   +1 more source

The negative association of low subjective socioeconomic status with future orientation: the protective role of low fatalism

BMC Psychology
Background Subjective socioeconomic status (SES), an individual’s beliefs about his or her social class, is anticipated to be related to future orientation.
Lingling Shu, Tianzi Gong, Yuting Wang, Qinggong Li, Zhiwen Xie   +4 more
doaj   +1 more source

Olfactory sensation emotion regulation: The implicit emotion regulation function of positive olfactory stimuli during emotional picture processing

NeuroImage
Previous research has shown that olfactory stimuli can induce emotional states, physiological and neural responses related to emotions. It remains unclear whether positive olfactory stimuli could down-regulate individuals’ negative emotions or up ...
Jiaotao Cai, Xinran Wang, Jiayi Zhou, Ye di, Ziruo Shen, Shuo An, Bingyang Long, Yicheng Wang, Zitong Li, Yiting Li, Si Chen, Yanmei Wang   +11 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Promoting positive adolescent sexual health & preventing teenage pregnancy - a review of recent effectiveness research

, 2004
This review was commissioned by the Crisis Pregnancy Agency to inform their work in the area of prevention of crisis pregnancy. The review commences with a brief description of the current epidemiological data on teenage pregnancy and adolescent ...
Fullerton, Deirdre
core  

Dynamic brain networks in spontaneous gestural communication

npj Science of Learning
Gestures accent and illustrate our communication. Although previous studies have uncovered the positive effects of gestures on communication, little is known about the specific cognitive functions of different types of gestures, or the instantaneous ...
Xinyue Wang, Kelong Lu, Yingyao He, Xinuo Qiao, Zhenni Gao, Yu Zhang, Ning Hao   +6 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Parafoveal Processing of Orthography, Phonology, and Semantics during Chinese Reading: Effects of Foveal Load

Brain Sciences
The foveal load hypothesis assumes that the ease (or difficulty) of processing the currently fixated word in a sentence can influence processing of the upcoming word(s), such that parafoveal preview is reduced when foveal load is high.
Lei Zhang, Liangyue Kang, Wanying Chen, Fang Xie, Kayleigh L. Warrington   +4 more
doaj   +1 more source