Results 101 to 110 of about 3,275,688 (215)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Healing the trauma of rape and sexual abuse (second report)

, 1995
Since the last RCC report was published the nation has been made tragically aware of sexual violence in our community, particularly as it affects defenceless children.
Rape Crisis Centre.
core  

Negative emotion alignment: The assimilation effect of facial emotion perception in a negative emotional crowd

i-Perception
Emotion perception of the target face within an emotional crowd is influenced by the intensity of surrounding emotional faces. The present study investigated whether participants perceived the target face's emotional intensity as more aligned with the ...
Jiaotao Cai, Yanmei Wang
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Towards a strategy to address the issue of crisis pregnancy

, 2003
The Crisis Pregnancy Agency was established in October 2001, under the Health (Corporate Bodies) Act, 1961, and governed by the Statutory Instrument No. 446 of 2001, Crisis Pregnancy Agency, Establishment Order, 2001.
Crisis Pregnancy Agency
core  

Network modeling of problematic social media use components in college student social media users

Frontiers in Psychiatry
BackgroundWhile the constitutive features of problematic social media use (PSMU) have been formulated, there has been a lack of studies in the field examining the structure of relationships among PSMU components.MethodThis study employed network analytic
Jianyong Chen, Jianyong Chen, Ting Su, Ting Su, Junqiang Dong, Yuzhi Li, Yuzhi Li, Ju Feng, Ju Feng, Yingxiu Chen, Yingxiu Chen, Gu Liu, Gu Liu   +12 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Strategy 2007 - 2011: Leading an integrated approach to reducing crisis pregnancy

, 2007
The Strategy for the Crisis Pregnancy Agency 2007 – 2011 focuses on three central objectives, derived from its mandates: • Reduce the number of crisis pregnancies.
Crisis Pregnancy Agency
core  

Thinking versus doing: how congruency between cognitive and actional future orientation affects left-behind children’s life satisfaction

BMC Psychology
Background Millions of children are left behind in rural areas of China while their parents work in urban areas, placing them at heightened risk for poor mental health outcomes.
Tong Zhao, Shuang Li, Ying Yang, Mohan Wang, Lijuan Cui   +4 more
doaj   +1 more source