Results 141 to 150 of about 119,569 (285)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Suicidal behaviour in adolescents with affective disorders: A study in a crisis intervention unit (CIU). [PDF]

open access: yesPLoS One
Valdevila Figueira JA   +10 more
europepmc   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

open access: yesFEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani   +7 more
wiley   +1 more source

Crisis Intervention Team Mental Health Training for Law Enforcement Officers: Protocol for a Multi-Site, Randomized, Controlled Trial. [PDF]

open access: yesPsychiatr Res Clin Pract
Compton MT   +10 more
europepmc   +1 more source

Bank Capital and Liquidity Risk: Influence of Crisis and Regulatory Intervention

open access: green
Mamiza Haq   +4 more
openalex   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Psychosocial crisis intervention for coronavirus disease 2019 patients and healthcare workers. [PDF]

open access: yesZhong Nan Da Xue Xue Bao Yi Xue Ban, 2023
Zhang L   +19 more
europepmc   +1 more source

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