Results 81 to 90 of about 322,656 (316)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Critical crisis management competencies: perspectives from universities of technology leadership
The South African Higher Education sector has faced challenging times recently, notably the #FeesMustFall student protest crisis, which inflicted damages exceeding R1 billion, and the COVID-19 pandemic, claiming over 102,000 lives in the nation.
Pharaoh, Courtley
core +1 more source
Crisis knowledge in tourism: types, flows and governance [PDF]
, 2013 Driven by the rapidly growing number of crises that affect tourism, the study of crisis knowledge management is gaining an increased interest in the tourism field.
McLean, Jacqueline +7 more
core +1 more source
Complex Automated Information System for Remote Management of Crisis Situations in Rail Transport
Communications, 2013 The paper deals with topical information from the area of crisis information support. The contributing authors work at three co-operating universities where the subject of transport support in crises is tackled.
Zdenek Dvorak +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Geospatial ICT support for crisis management and response
, 2015 7 S.Efficient crisis response and management requires well-informed actors and stakeholders and effective means for communication and policy enforcement. A secure and dependable geospatial information and communication technology (ICT) infrastructure may
Usländer, Thomas, Simonis, I.
core +1 more source