Results 221 to 230 of about 1,216,467 (232)

UNCOVERseq enables sensitive and controlled gene editing off-target nomination across CRISPR-Cas modalities and systems. [PDF]

Nat Commun
Kinney KJ, Jia K, Zhang H, Schmaljohn E, Osborne T, Thommandru B, Murugan K, Sánchez-Peña A, West S, Chen S, Codipilly R, Sturgeon M, Turk R, McNeill MS, Behlke M, Jacobi A, Cromer MK, Rettig G, Kurgan GL.   +18 more
europepmc   +1 more source

Pathological Signal‐Responsive Nanoplatforms for Sepsis: Integrating Biomarker Sensing With Spatiotemporal Drug Delivery and Immunomodulation

Advanced Science, EarlyView.
Biomarker‐triggered nanoplatforms transform sepsis therapy by coupling pathological sensing with precision drug release. This review reveals how microenvironment‐responsive nanomedicines enable stage‐specific intervention, improve therapeutic efficacy, and minimize systemic toxicity, while highlighting emerging opportunities for AI‐assisted and ...
Yukun Liu, Kang Wang, Kwet Kyawl Yan, Zhikai Xu, Xuan Zhao, Xiangjun Bai, Zhanfei Li, Yuchang Wang   +7 more
wiley   +1 more source

The role of bacteriophages and CRISPR-Cas in combating multidrug-resistant bacteria. [PDF]

Nat Prod Bioprospect
Ghazaei C.
europepmc   +1 more source

Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture

Advanced Science, EarlyView.
This study integrates rice immune perception, signal transduction, and resistance output into a multi‐omics framework. By combining high‐throughput sequencing, phenomics, and AI‐assisted design with marker‐assisted selection, gene editing, and rapid domestication, we aim to accelerate the precise breeding of disease‐resistant rice varieties by ...
Xinyue Hou, Yuanjiang Cui, Chaoqing Ding, Qian Qian, Deyong Ren   +4 more
wiley   +1 more source

Recent advances in rapid multiplex detection of nucleic acid markers using RPA and CRISPR-Cas. [PDF]

Front Microbiol
Li X, Huang Y, Zhang X, Du L, Qiu Y, Jiang L.   +5 more
europepmc   +1 more source

Design of a Novel Diamine Biosensor to Guide the Engineering of Escherichia coli for Cadaverine Overproduction

Advanced Science, EarlyView.
A high‐throughput screening platform was established by integrating an in vivo cadaverine biosensor with a fluorescence‐activated cell sorting (FACS) system. Biosensor‐driven specific exporter tuning, pathway optimization and genome‐wide target mining were conducted to maximize cadaverine production in Escherichia coli.
Jia Feng, Getao Liu, Ding Ma, Jiaxiang Yuan, Xinyi Zhang, Weihao Wang, Chen Ma, Yang Liao, Siyuan Gao, Lei Qin, Jiao Feng, Sheng Xu, Xin Wang, Kequan Chen   +13 more
wiley   +1 more source

A tailored phosphorothioate coordinator enables CRISPR/Cas in-situ amplification. [PDF]

Nucleic Acids Res
Yang T, Tang M, Xu L, Jiang L, Jiang L, Zou Y, Wang J, Liu Z, Chen F, Ban Y, Ren W, Cheng W.   +11 more
europepmc   +1 more source

Mismatch type impacts interference and priming activities in the type I-E CRISPR-Cas system. [PDF]

J Biol Chem
Phan PT, Ozturk M, Dougherty EM, Ravishankar J, Xue C, Sashital DG.   +5 more
europepmc   +1 more source

The stress of carrying CRISPR-Cas. [PDF]

Virulence
Haider D, Bauer R, Grempels A, Roscher R, Aslan CC, Mauerer S, Spellerberg B.   +6 more
europepmc   +1 more source

Application and Research Prospects of CRISPR/Cas Gene Editing Technology in Lactic Acid Bacteria. [PDF]

Microorganisms
Zhang E, Yan J, Du J, Chu X, Chen D.
europepmc   +1 more source