Results 31 to 40 of about 79,886 (234)

Clades of huge phages from across Earth's ecosystems. [PDF]

, 2020
Bacteriophages typically have small genomes1 and depend on their bacterial hosts for replication2. Here we sequenced DNA from diverse ecosystems and found hundreds of phage genomes with lengths of more than 200 kilobases (kb), including a genome of ...
Al-Shayeb, Basem, Amano, Yuki, Amundson, Ronald, Anantharaman, Karthik, Banfield, Jillian F, Borton, Mikayla A, Bouma-Gregson, Keith, Brooks, Brandon, Castelle, Cindy J, Cate, Jamie HD, Chen, Lin-Xing, Devoto, Audra, Doudna, Jennifer A, Farag, Ibrahim F, Finstad, Kari, Goltsman, Daniela SA, Harrison, Sue, He, Christine, Jaffe, Alexander L, Kantor, Rose, Keren, Ray, Lane, Katherine R, Lavy, Adi, Lehours, Anne-Catherine, Lei, Shufei, Li, Wen-Jun, Matheus-Carnevali, Paula, Morowitz, Michael, Munk, Patrick, Méheust, Raphaël, Nelson, Tara C, Olm, Matthew R, Power, Mary E, Probst, Alexander J, Relman, David A, Sachdeva, Rohan, Santini, Joanne M, Sharrar, Allison, Sun, Christine, Thomas, Alex, Tringe, Susannah G, Ward, Fred, Warren, Lesley, Wrighton, Kelly, Zhou, Jinglie   +44 more
core   +2 more sources

Characterization of 67 Confirmed Clustered Regularly Interspaced Short Palindromic Repeats Loci in 52 Strains of Staphylococci

Frontiers in Microbiology, 2021
Staphylococcus aureus (S. aureus), which is one of the most important species of Staphylococci, poses a great threat to public health. Clustered regularly interspaced short palindromic repeats (CRISPR) and their CRISPR-associated proteins (Cas) are an ...
Ying Wang, Tingting Mao, Yinxia Li, Wenwei Xiao, Xuan Liang, Guangcai Duan, Haiyan Yang   +6 more
doaj   +1 more source

Dealing with the evolutionary downside of CRISPR immunity: bacteria and beneficial plasmids. [PDF]

PLoS Genetics, 2013
The immune systems that protect organisms from infectious agents invariably have a cost for the host. In bacteria and archaea CRISPR-Cas loci can serve as adaptive immune systems that protect these microbes from infectiously transmitted DNAs.
Wenyan Jiang, Inbal Maniv, Fawaz Arain, Yaying Wang, Bruce R Levin, Luciano A Marraffini   +5 more
doaj   +1 more source

Genome editing technologies to fight infectious diseases [PDF]

, 2017
Genome editing by programmable nucleases represents a promising tool that could be exploited to develop new therapeutic strategies to fight infectious diseases.
Barzon, Luisa, Pal\ue3\ub9, Giorgio, Trevisan, Marta   +2 more
core   +1 more source

Characterization of CRISPR-Cas Systems in Clinical Klebsiella pneumoniae Isolates Uncovers Its Potential Association With Antibiotic Susceptibility

Frontiers in Microbiology, 2018
Prokaryotic CRISPR-Cas systems limit the acquisition of genetic elements and provide immunity against invasive bacteriophage. The characteristics of CRISPR-Cas systems in clinical Klebsiella pneumoniae isolates are still unknown. Here, 97 K.
Hsin-Yu Li, Cheng-Yen Kao, Wei-Hung Lin, Po-Xing Zheng, Jing-Jou Yan, Ming-Cheng Wang, Ching-Hao Teng, Chin-Chung Tseng, Jiunn-Jong Wu   +8 more
doaj   +1 more source

MOESM1 of CRISPRâ Cas ribonucleoprotein mediated homology-directed repair for efficient targeted genome editing in microalgae Nannochloropsis oceanica IMET1

, 2019
Additional file 1. Supplementary file.
Mihris Naduthodi, Prarthana Mohanraju, SĂźdfeld, Christian, D’Adamo, Sarah, Barbosa, Maria, Oost, John Van Der   +5 more
openaire   +1 more source

Additional file 1: of Not all predicted CRISPRâ Cas systems are equal: isolated cas genes and classes of CRISPR like elements

, 2017
A phylogenetic tree of 49S. pyogenes complete genomes. (DOCX 96 kb)
Zhang, Quan, Yuzhen Ye
openaire   +1 more source

Research Progress on Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-Associated Protein (Cas)-Isothermal Amplification in the Detection of Foodborne Pathogens [PDF]

Shipin Kexue
Food safety incidents caused by foodborne pathogens have attracted widespread attention. In order to ensure food safety, it is essential to adopt effective detection means.
ZHANG Qi, PANG Lidong, SU Qunchao, SONG Danliangmin, YANG Xinyan, JIANG Yujun, ZHANG Wei
doaj   +1 more source

Development and Application of CRISPR/Cas in Microbial Biotechnology

Frontiers in Bioengineering and Biotechnology, 2020
The clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) system has been rapidly developed as versatile genomic engineering tools with high efficiency, accuracy and flexibility, and has revolutionized traditional methods ...
Wentao Ding, Wentao Ding, Yang Zhang, Shuobo Shi   +3 more
doaj   +1 more source

Optimization of CRISPR–Cas system for clinical cancer therapy

Bioengineering & Translational Medicine, 2023
Cancer is a genetic disease caused by alterations in genome and epigenome and is one of the leading causes for death worldwide. The exploration of disease development and therapeutic strategies at the genetic level have become the key to the treatment of
Xiang Meng, Tian‐gang Wu, Qiu‐yue Lou, Kai‐yuan Niu, Lei Jiang, Qing‐zhong Xiao, Tao Xu, Lei Zhang   +7 more
doaj   +1 more source