Results 91 to 100 of about 1,254,871 (374)
The size of the immune repertoire of bacteria
, 2019 Some bacteria and archaea possess an immune system, based on the CRISPR-Cas mechanism, that confers adaptive immunity against phage. In such species, individual bacteria maintain a "cassette" of viral DNA elements called spacers as a memory of past ...
Balasubramanian, Vijay +3 more
core +1 more source
Protein-nucleic acids interactions: new ways of connecting structure, dynamics and function [PDF]
, 2017 No abstract ...
Smith, Brian O., Spies, Maria
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Epidemiological and evolutionary consequences of different types of CRISPR-Cas systems.
PLoS Computational Biology, 2022 Bacteria have adaptive immunity against viruses (phages) in the form of CRISPR-Cas immune systems. Currently, 6 types of CRISPR-Cas systems are known and the molecular study of three of these has revealed important molecular differences. It is unknown if
Hélène Chabas +3 more
doaj +1 more source
Should Parents Genetically Engineer their Children? [PDF]
, 2019 Imagine a world where everyone is healthy, intelligent, long living and happy. Intuitively this seems wonderful, albeit unrealistic. However, recent scientific developments in genetic engineering, namely CRISPR/Cas bring the question into public ...
Veit, Walter
core
Aplicación de la nanobiotecnología con el sistema CRISPR-cas [PDF]
, 2017 Introduction: Nanobiotechnology and synthetic biology are sciences that impact today with the launching of innovative and beneficial applications for the human being. These sciences have been amalgamated to manufacture new components for the construction
Angarita-Merchán, Maritza +2 more
core +2 more sources
Genetic modification strategies for electroporation and CRISPR-Cas-based technologies in the non-competent Gram-negative bacterium Acinetobacter sp. Tol 5 [PDF]
, 2023 Masahito Ishikawa, Katsutoshi Hori
openalex +1 more source
CRISPR-Cas Biochemistry and CRISPR-Based Molecular Diagnostics.
Angewandte Chemie, 2023 Polymerase chain reaction (PCR)-based nucleic acid testing has played a critical role in disease diagnostics, pathogen surveillance, and many more. However, this method requires a long turnaround time, expensive equipment, and trained personnel, limiting
Zhengyan Weng +7 more
semanticscholar +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
OffScan: a universal and fast CRISPR off-target sites detection tool
BMC Genomics, 2020 Background The Type II clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas) is a powerful genome editing technology, which is more and more popular in gene function analysis.
Yingbo Cui +5 more
doaj +1 more source