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Effectiveness of CRISPR-Cas in sensitizing bacterial populations with plasmid-encoded antimicrobial resistance. [PDF]
GeneticsKippnich J +3 more
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Characterization and engineering of a type IV-A3 CRISPR-Cas system for genome editing in Escherichia coli. [PDF]
Nucleic Acids ResSemsey S +11 more
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CRISPR-Cas-mediated diagnostics
Trends in Biotechnology, 2022An ideal molecular diagnostic method should be sensitive, specific, low cost, rapid, portable, and easy to operate. Traditional nucleic acid detection methods based mainly on PCR technology have not only high sensitivity and specificity, but also some limitations, such as the need for expensive equipment and skilled technicians, being both time and ...
Luoxi, Li +5 more
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Methods, 2020
Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated proteins (Cas) are essential genetic elements in many archaeal and bacterial genomes, playing a key role in a prokaryote adaptive immune system against invasive foreign elements.
Alkhnbashi, Omer S. +4 more
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Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated proteins (Cas) are essential genetic elements in many archaeal and bacterial genomes, playing a key role in a prokaryote adaptive immune system against invasive foreign elements.
Alkhnbashi, Omer S. +4 more
openaire +3 more sources
Chemie in unserer Zeit, 2017
ZusammenfassungCRISPR‐Cas ist ein adaptives und vererbbares Immunsystem, mit dem sich Prokaryoten gegen invasive genetische Elemente wie Viren wehren. Es eignet sich aber auch hervorragend zur Manipulation von Genomen. Die Nuklease Cas9 wird durch eine Leit‐RNA zu einem bestimmten DNA‐Abschnitt geführt und fügt dort einen Doppelstrangbruch ein.
Larissa Tetsch +2 more
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ZusammenfassungCRISPR‐Cas ist ein adaptives und vererbbares Immunsystem, mit dem sich Prokaryoten gegen invasive genetische Elemente wie Viren wehren. Es eignet sich aber auch hervorragend zur Manipulation von Genomen. Die Nuklease Cas9 wird durch eine Leit‐RNA zu einem bestimmten DNA‐Abschnitt geführt und fügt dort einen Doppelstrangbruch ein.
Larissa Tetsch +2 more
openaire +2 more sources
Biologie in unserer Zeit, 2013
AbstractEiner der ältesten Konflikte auf Erden ist vermutlich der Existenzkampf zwischen Prokaryoten und Viren. Prokaryoten haben verschiedene Abwehrstrategien entwickelt, um sich gegen die allgegenwärtigen und zahlenmäßig überlegenen Viren zu schützen. Letztere besitzen wiederum Gegenmechanismen, mit denen sie den prokaryotischen Schutz umgehen.
Anita Marchfelder +3 more
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AbstractEiner der ältesten Konflikte auf Erden ist vermutlich der Existenzkampf zwischen Prokaryoten und Viren. Prokaryoten haben verschiedene Abwehrstrategien entwickelt, um sich gegen die allgegenwärtigen und zahlenmäßig überlegenen Viren zu schützen. Letztere besitzen wiederum Gegenmechanismen, mit denen sie den prokaryotischen Schutz umgehen.
Anita Marchfelder +3 more
openaire +1 more source
CRISPR/Cas‐Based MicroRNA Biosensors
Chemistry – A European Journal, 2023AbstractAs important post‐transcriptional regulators, microRNAs (miRNAs) play irreplaceable roles in diverse cellular functions. Dysregulated miRNA expression is implicated in various diseases including cancers, and thus miRNAs have become the valuable biomarkers for disease monitoring.
Qian Zhang +4 more
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RNA-targeting CRISPR–Cas systems
Nature Reviews Microbiology, 2022CRISPR-Cas is a widespread adaptive immune system in bacteria and archaea that protects against viral infection by targeting specific invading nucleic acid sequences. Whereas some CRISPR-Cas systems sense and cleave viral DNA, type III and type VI CRISPR-Cas systems sense RNA that results from viral transcription and perhaps invasion by RNA viruses ...
Sam P. B. van Beljouw +3 more
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Journal of Cellular Physiology, 2020
AbstractClustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated enzyme (Cas) is a naturally occurring genome editing tool adopted from the prokaryotic adaptive immune defense system. Currently, CRISPR/Cas9‐based genome editing has been becoming one of the most promising tools for treating human genetic diseases, including ...
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AbstractClustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated enzyme (Cas) is a naturally occurring genome editing tool adopted from the prokaryotic adaptive immune defense system. Currently, CRISPR/Cas9‐based genome editing has been becoming one of the most promising tools for treating human genetic diseases, including ...
openaire +2 more sources