Results 31 to 40 of about 54,706 (289)
Special focus CRISPR-Cas [PDF]
RNA Biology, 2013 Six years ago a new sophisticated prokaryotic defense system was identified that was termed CRISPR-Cas (CRISPR, clustered regularly interspaced short palindromic repeats; Cas, CRISPR associated).1-...
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Adaptation in CRISPR-Cas Systems [PDF]
Molecular Cell, 2016 Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system in prokaryotes. The system preserves memories of prior infections by integrating short segments of foreign DNA, termed spacers, into the CRISPR array in a process termed adaptation.
Samuel H. Sternberg +3 more
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Dealing with the evolutionary downside of CRISPR immunity: bacteria and beneficial plasmids. [PDF]
PLoS Genetics, 2013 The immune systems that protect organisms from infectious agents invariably have a cost for the host. In bacteria and archaea CRISPR-Cas loci can serve as adaptive immune systems that protect these microbes from infectiously transmitted DNAs.
Wenyan Jiang +5 more
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Frontiers in Microbiology, 2018 Prokaryotic CRISPR-Cas systems limit the acquisition of genetic elements and provide immunity against invasive bacteriophage. The characteristics of CRISPR-Cas systems in clinical Klebsiella pneumoniae isolates are still unknown. Here, 97 K.
Hsin-Yu Li +8 more
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CRISPR-Cas: Adapting to change
Science, 2017 Variation in prokaryote adaptive immunity To repel infection by phage and mobile genetic elements, prokaryotes have a form of adaptive immune response and memory invested in clustered regularly interspaced short palindromic repeats and associated proteins (CRISPR-Cas).
Jackson, Simon A. +5 more
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CRISPR-Cas Systems in Streptococci [PDF]
Current Issues in Molecular Biology, 2019 Streptococci are one of the most important and common constituents of the host's microbiota and can colonize and live in the upper respiratory and urogenital tract of humans and animals. The CRISPR-Cas systems (i.e., clustered regularly interspaced short palindromic repeat, with CRISPR-associated proteins) found in bacteria and archaea provide sequence-
Tao, Gong +7 more
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Research Progress on Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-Associated Protein (Cas)-Isothermal Amplification in the Detection of Foodborne Pathogens [PDF]
Shipin KexueFood safety incidents caused by foodborne pathogens have attracted widespread attention. In order to ensure food safety, it is essential to adopt effective detection means.
ZHANG Qi, PANG Lidong, SU Qunchao, SONG Danliangmin, YANG Xinyan, JIANG Yujun, ZHANG Wei
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Development and Application of CRISPR/Cas in Microbial Biotechnology
Frontiers in Bioengineering and Biotechnology, 2020 The clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) system has been rapidly developed as versatile genomic engineering tools with high efficiency, accuracy and flexibility, and has revolutionized traditional methods ...
Wentao Ding +3 more
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Optimization of CRISPR–Cas system for clinical cancer therapy
Bioengineering & Translational Medicine, 2023 Cancer is a genetic disease caused by alterations in genome and epigenome and is one of the leading causes for death worldwide. The exploration of disease development and therapeutic strategies at the genetic level have become the key to the treatment of
Xiang Meng +7 more
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mBio, 2021 CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated) systems provide prokaryotes with efficient protection against foreign nucleic acid invaders. We have recently demonstrated the defensive interference function of a
Anna Maikova +8 more
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