Results 61 to 70 of about 1,254,871 (374)
CRISPR-Cas guides the future of genetic engineering
Science, 2018 The diversity, modularity, and efficacy of CRISPR-Cas systems are driving a biotechnological revolution. RNA-guided Cas enzymes have been adopted as tools to manipulate the genomes of cultured cells, animals, and plants, accelerating the pace of ...
G. Knott, J. Doudna
semanticscholar +1 more source
mBio, 2021 CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated) systems provide prokaryotes with efficient protection against foreign nucleic acid invaders. We have recently demonstrated the defensive interference function of a
Anna Maikova +8 more
doaj +1 more source
On the origin of reverse transcriptase-using CRISPR-Cas systems and their hyperdiverse, enigmatic spacer repertoires [PDF]
, 2017 et al, +2 more
core +4 more sources
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
Genome Research, 2014 RNA-guided endonucleases (RGENs), derived from the prokaryotic adaptive immune system known as CRISPR/Cas, enable targeted genome engineering in cells and organisms.
S. Cho +6 more
semanticscholar +1 more source
Cancer Gene Therapy, 2023 Gene editing-based therapeutic strategies grant the power to override cell machinery and alter faulty genes contributing to disease development like cancer.
S. Ahmadi +6 more
semanticscholar +1 more source
New CRISPR-Cas systems discovered [PDF]
Cell Research, 2017 In bacteria and archaea, CRISPR-Cas adaptive immune systems utilize RNA-guided endonucleases to defend against invasion by foreign nucleic acids of bacteriophage, virus and plasmid origin. In a recent paper published in Nature, Burstein et al. identified the first Cas9 protein in uncultivated archaea and two novel CRISPR-CasX and CRISPR-CasY systems in
Hui, Yang, Dinshaw J, Patel
openaire +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Microorganisms, 2023 The CRISPR/Cas system has been long known to interfere with the acquisition of foreign genetic elements and was recommended as a tool for fighting antimicrobial resistance.
Amany K. Alkompoz +5 more
doaj +1 more source
How the other half lives: CRISPR-Cas's influence on bacteriophages
, 2017 CRISPR-Cas is a genetic adaptive immune system unique to prokaryotic cells used to combat phage and plasmid threats. The host cell adapts by incorporating DNA sequences from invading phages or plasmids into its CRISPR locus as spacers.
AE Briner +35 more
core +1 more source
A Cryptic Non-Inducible Prophage Confers Phage-Immunity on the Streptococcus thermophilus M17PTZA496 [PDF]
, 2018 open9openda Silva Duarte, Vinícius; Giaretta, Sabrina; Campanaro, Stefano; Treu, Laura; Armani, Andrea; Tarrah, Armin; Oliveira de Paula, Sérgio; Giacomini, Alessio; Corich, Vivianada Silva Duarte, Vinícius; Giaretta, Sabrina; Campanaro, Stefano; Treu ...
core +1 more source