Results 81 to 90 of about 54,706 (289)
Drug Inducible CRISPR/Cas Systems
Computational and Structural Biotechnology Journal, 2019 Clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) systems have been employed as a powerful versatile technology for programmable gene editing, transcriptional modulation, epigenetic modulation, and genome labeling, etc.
Jingfang Zhang +3 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Patient‐derived cardiac organoids reveal key features of Duchenne muscular dystrophy cardiomyopathy, including apoptosis, oxidative stress, calcium handling defects, and mechanical remodeling. By integrating organoids into alginate–gelatin bioprinted constructs, disease phenotypes are organized into scalable 3D cardiac tissues displaying extracellular ...
Vittoria Marini +15 more
wiley +1 more source
Mechanism for Cas4-assisted directional spacer acquisition in CRISPR–Cas
, 2021 Chunyi Hu +8 more
openalex +2 more sources
CRISPR-Cas: Revolutionising genome engineering
South African Medical Journal, 2016 The ability to permanently alter or repair the human genome has been the subject of a number of science fiction films, but with the recent advent of several customisable sequence-specific endonuclease technologies, genome engineering looks set to become a clinical reality in the near future.
Nicholson, S.A., Pepper, Michael Sean
openaire +6 more sources
Advanced Healthcare Materials, EarlyView.This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi +2 more
wiley +1 more source
Insight into the natural regulatory mechanisms and clinical applications of the CRISPR-Cas system
HeliyonCRISPR-Cas, the adaptive immune system exclusive to prokaryotes, confers resistance against foreign mobile genetic elements. The CRISPR-Cas system is now being exploited by scientists in a diverse range of genome editing applications.
Hui Cheng +7 more
doaj +1 more source
Control of Bacterial Diseases of Banana Using CRISPR/Cas-Based Gene Editing [PDF]
, 2022 Leena Tripathi +2 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.Schematic diagram depicting the fabrication and application of thymosin β4 (Tβ4)‐loaded microneedle patches for wound treatment. The Tβ4 was loaded into chitosan (CS) and sucrose MNs under mild conditions (4°C, 65% relative humidity). The Tβ4 MN patch specifically binds to the downregulated immune regulators Vsig4 and IL22rα2, thereby accelerating ...
Shilong He +4 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram +10 more
wiley +1 more source
Disabling a Type I-E CRISPR-Cas Nuclease with a Bacteriophage-Encoded Anti-CRISPR Protein
mBio, 2017 CRISPR (clustered regularly interspaced short palindromic repeat)-Cas adaptive immune systems are prevalent defense mechanisms in bacteria and archaea.
April Pawluk +6 more
doaj +1 more source