Results 251 to 260 of about 18,275,652 (330)

CRISPR/Cas system and its application in the diagnosis of animal infectious diseases. [PDF]

FASEB J
Rasool HMH, Chen Q, Gong X, Zhou J.
europepmc   +1 more source

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

Inducible CRISPR/Cas systems in precision oncology: Current applications and future perspectives

Ziliang Ding, Yukun Wei, Yong Han, Pengfei Gu   +3 more
openalex   +1 more source

The application of CRISPR-Cas system in Staphylococcus aureus infection. [PDF]

Heliyon
Wang J, Liu F, Long J, Jin Y, Chen S, Duan G, Yang H.   +6 more
europepmc   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Ordered assembly of Cas12a for better performance of CRISPR/Cas system with application to the diagnosis of dental caries

Yining Zhao, Panpan Qiao, Yujing Zeng, Murtaza Sayed, Qin Mi, Juan Zhang, Genxi Li   +6 more
openalex   +1 more source

Research Progress on the Mechanism and Application of the Type I CRISPR-Cas System. [PDF]

Int J Mol Sci
Yang P, Zhang S, Hu D, Li X, Guo Y, Guo H, Zhang L, Ding X.   +7 more
europepmc   +1 more source

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

CRISPR–Cas Systems as Precision Antimicrobials: Delivery Strategies and Challenges in Combating Antimicrobial Resistance

G. Deepan, A. P. Venkateswara, B. Dayana Priyatharshini, R. Dhinesh   +3 more
openalex   +1 more source

AI assisted optimization of CRISPR Cas systems and functional gene screening in cucurbit crops [PDF]

Chengchuang Huang
openalex   +1 more source