Results 251 to 260 of about 75,041 (301)

Recent Advances in CRISPR/Cas System-Based Biosensors for the Detection of Foodborne Pathogenic Microorganisms. [PDF]

Micromachines (Basel)
Xie S, Yue Y, Yang F.
europepmc   +1 more source

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, EarlyView.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source

Rapid detection of pathogenic E. coli based on CRISPR Cas system. [PDF]

Front Microbiol
Rathore P, Basnet A, Kilonzo-Nthenge A, Dumenyo K, Yadegari Z, Taheri A.   +5 more
europepmc   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Author Correction: Discovering CRISPR-Cas system with self-processing pre-crRNA capability by foundation models. [PDF]

Nat Commun
Li W, Jiang X, Wang W, Hou L, Cai R, Li Y, Gu Q, Chen Q, Ma P, Tang J, Guo M, Chuai G, Huang X, Zhang J, Liu Q.   +14 more
europepmc   +1 more source

Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants

Advanced Science, EarlyView.
A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei, Kai Zhang, Shuke Deng, Jinjie Chen, Xiaomei Huang, Jingfei Guo, Yuqing Wu, Yingjie Guo, Zhen Liang   +8 more
wiley   +1 more source

Structural basis of Cas3 activation in type I-C CRISPR-Cas system. [PDF]

Nucleic Acids Res
Kim DY, Lee SY, Ha HJ, Park HH.
europepmc   +1 more source

Multiplexed CRISPR-Cas system targeting ASFV genes in vivo: solution lies within. [PDF]

Microbiol Spectr
Zhang M, Lang Y, Li W.
europepmc   +1 more source

Erratum for Irfan et al., "A <i>Porphyromonas gingivalis</i> hypothetical protein controlled by the type I-B CRISPR-Cas system is a novel adhesin important in virulence". [PDF]

mSystems
Irfan M, Solbiati J, Duran-Pinedo A, Rocha FG, Gibson FC, Frias-Lopez J.   +5 more
europepmc   +1 more source

Current Updates of CRISPR/Cas System and Anti-CRISPR Proteins: Innovative Applications to Improve the Genome Editing Strategies. [PDF]

Int J Nanomedicine
Allemailem KS, Almatroudi A, Alrumaihi F, Alradhi AE, Theyab A, Algahtani M, Alhawas MO, Dobie G, Moawad AA, Rahmani AH, Khan AA.   +10 more
europepmc   +1 more source