Results 241 to 250 of about 18,275,652 (330)

A census of anti-CRISPR proteins reveals AcrIE9 and AcrIE13 as inhibitors of the Escherichia coli K12 type IE CRISPR-Cas system

Dmitry Taranenko, Oksana Kotovskaya, Konstantin Kuznedelov, Daria Yanovskaya, Alina Demkina, Sofya Fardeeva, Viktor Mamontov, Kaiya Vierra, Nathaniel Burman, Dan Li, Minggui Wang, Blake Wiedenheft, Konstantin Severinov, Е. А. Семенова, Artem Isaev   +14 more
openalex   +1 more source

Efficient, compact, and versatile: Type I-F2 CRISPR-Cas system. [PDF]

mLife
Ma S, Zhang S, Liu K, Hu T, Hu C.
europepmc   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

Exploring the emerging role of CRISPR-Cas systems in probiotic development

Abrar Hussain, Naheed Mojgani, Maria Fareed Siddiqui, Mohammad Inam Khan, Syed Abid Ali   +4 more
openalex   +1 more source

AcrIE7 inhibits the CRISPR-Cas system by directly binding to the R-loop single-stranded DNA. [PDF]

Proc Natl Acad Sci U S A
Kim DY, Lee SY, Ha HJ, Park HH.
europepmc   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

CRISPR/CAS-MEDIATED BIOFORTIFICATION OF WHEAT FOR ENHANCED ZINC AND IRON CONTENT UNDER CLIMATE- RESILIENT FARMING SYSTEMS IN PAKISTAN

Qurban Ali Magsi,Gul Hassan Shah,Maria Khan Pathan,Khadija Abraq,Tahir Naveed
  +4 more sources

Efficient genome editing in dicot plants using calreticulin promoter-driven CRISPR/Cas system. [PDF]

Mol Hortic
Li B, Shang Y, Wang L, Lv J, Wu Q, Wang F, Chao J, Mao J, Ding A, Wu X, Xue K, Chen C, Cui M, Sun Y, Zhang H, Dai C.   +15 more
europepmc   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

CRISPR-Cas systems in protozoan parasites: A biological-fit decision framework for Cas9/Cas12a editing and dCas-based regulation

Jianqi Yuan, Shaoxiong Liu, Qiankun Yang, Qinqiin Jin, Yukun Le, Lili Cao, Pengtao Gong   +6 more
openalex   +1 more source