Results 291 to 300 of about 216,867 (346)

Current Updates of CRISPR/Cas System and Anti-CRISPR Proteins: Innovative Applications to Improve the Genome Editing Strategies. [PDF]

Int J Nanomedicine
Allemailem KS, Almatroudi A, Alrumaihi F, Alradhi AE, Theyab A, Algahtani M, Alhawas MO, Dobie G, Moawad AA, Rahmani AH, Khan AA.   +10 more
europepmc   +1 more source

Engineered minimal type I CRISPR-Cas system for transcriptional activation and base editing in human cells. [PDF]

Nat Commun
Guo J, Gong L, Yu H, Li M, An Q, Liu Z, Fan S, Yang C, Zhao D, Han J, Xiang H.   +10 more
europepmc   +1 more source

The type III-B CRISPR-Cas System Affects Energy Metabolism and Adaptation in the Archaeon Saccharolobus solfataricus

Wimmer E, Hodgskiss LH, Kerou M, Zink IA, Schleper C.   +4 more
europepmc   +1 more source

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RNA-targeting CRISPR–Cas systems

Nature Reviews Microbiology, 2022
CRISPR-Cas is a widespread adaptive immune system in bacteria and archaea that protects against viral infection by targeting specific invading nucleic acid sequences. Whereas some CRISPR-Cas systems sense and cleave viral DNA, type III and type VI CRISPR-Cas systems sense RNA that results from viral transcription and perhaps invasion by RNA viruses ...
Sam P. B. van Beljouw, Jasper Sanders, Alicia Rodríguez-Molina, Stan J. J. Brouns   +3 more
exaly   +7 more sources

CRISPR-Cas system as a promising player against bacterial infection and antibiotic resistance.

Drug resistance updates, 2023
The phenomenon of antibiotic resistance (AR) and its increasing global trends and destructive waves concerns patients and the healthcare system. In order to combat AR, it is necessary to explore new strategies when the current antibiotics fail to be ...
Mohammad Abavisani, Reza Khayami, Melika Hoseinzadeh, M. Kodori, Prashant Kesharwani, A. Sahebkar   +5 more
semanticscholar   +1 more source

CRISPR/Cas System: The Accelerator for the Development of Non-nucleic Acid Target Detection in Food Safety.

Journal of Agricultural and Food Chemistry, 2023
Non-nucleic acid targets have posed a serious challenge to food safety. The detection of non-nucleic acid targets can enable us to monitor food contamination in a timely manner.
Yaru Li, Zhiying Zhao, Yajie Liu, Nan Wang, S. Man, Long Ma, Shuo Wang   +6 more
semanticscholar   +1 more source

Versatile detection with CRISPR/Cas system from applications to challenges

Trends in Analytical Chemistry (TrAC), 2021
CRISPR/Cas system is now playing an important role in biosensing applications, especially when the trans cleavage activity of several Cas effectors is discovered. Recently, CRISPR/Cas system combining with multiple detection techniques has been developed
Hui Wu, Xiaoyun Chen, Mengyao Zhang, Xiaofu Wang, Yanju Chen, Cheng Qian, Jian Wu, Junfeng Xu   +7 more
semanticscholar   +1 more source

Advances in amplification-free detection of nucleic acid: CRISPR/Cas system as a powerful tool.

Analytical Biochemistry, 2022
Amplification technologies such as polymerase chain reaction (PCR) play an important role in nucleic acid detection. However, they require bulky and sophisticated thermal cycling instrument, as well as are prone to get false-positive results due to ...
Siwenjie Qian, Yanju Chen, Xiaoli Xu, Cheng Peng, Xiaofu Wang, Hui Wu, Yang Liu, Xiaoping Zhong, Junfeng Xu, Jian Wu   +9 more
semanticscholar   +1 more source

Enhancing CRISPR/Cas systems with nanotechnology

Trends in Biotechnology, 2023
CRISPR/Cas systems have revolutionized biology and medicine, and have led to new paradigms in disease diagnostics and therapeutics. However, these complexes suffer from key limitations regarding barriers to cellular entry, stability in biological environments, and off-target effects.
Rupali Chowdhry, Steven Z. Lu, Seungheon Lee, Shivudu Godhulayyagari, Sasha B. Ebrahimi, Devleena Samanta   +5 more
openaire   +2 more sources

Recent advances on CRISPR/Cas system-enabled portable detection devices for on-site agri-food safety assay

Trends in Food Science & Technology, 2022
Background Agri-food safety has been considered as one of the most important public concerns worldwide. From farm to table, food crops and foods are extremely vulnerable to the contamination by a variety of pollutants from their growth and processing ...
Manyan Qiu, Jingwen Zhang, Lidong Pang, Yu Zhang, Qianyu Zhao, Yujun Jiang, Xinyan Yang, C. Man   +7 more
semanticscholar   +1 more source