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CRISPR–Cas systems: beyond adaptive immunity
Nature Reviews Microbiology, 2014The discovery of CRISPR-Cas (clustered, regularly interspaced short palindromic repeats-CRISPR-associated proteins) adaptive immune systems in prokaryotes has been one of the most exciting advances in microbiology in the past decade. Their role in host protection against mobile genetic elements is now well established, but there is mounting evidence ...
Edze R, Westra +2 more
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CRISPR/Cas System: An Introduction
2021The process of altering genetic code to modify DNA precisely and efficiently within a cell is known as genome editing. All techniques used for changing a gene in a cell are based on cutting of double-stranded DNA through DNA endonucleases at specific site.
Nayla Munawar, Aftab Ahmad
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Bacteriophages and phage-delivered CRISPR-Cas system as antibacterial therapy.
International Journal of Antimicrobial Agents, 2021Multidrug-resistant (MDR) bacterial infections in humans are increasing worldwide. The global spread of antimicrobial resistance poses a considerable threat to human health. Phage therapy is a promising approach to combat MDR bacteria.
Ting-Kuang Yeh +7 more
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CRISPR-Cas systems in Serratia
2022The CRISPR-Cas system of Prokaryotes is an adaptive immune defense mechanism to protect themselves from invading genetic elements (e.g. phages and plasmids). Studies that describe the genetic organization of these prokaryotic systems have mainly reported on the Enterobacteriaceae family (now reorganized within the order Enterobacteriales).
Maria Scrascia +8 more
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The CRISPR-Cas system in molecular diagnostics.
Clinica chimica acta; international journal of clinical chemistryRobust, sensitive, and rapid molecular detection tools are essential prerequisites for disease diagnosis and epidemiological control. However, the current mainstream tests necessitate expensive equipment and specialized operators, impeding the ...
Rao Song +3 more
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Advances in Field Detection Based on CRISPR/Cas System.
ACS Synthetic Biology, 2021Rapid and accurate diagnostic methods are essential to interrupt outbreaks of infectious diseases such as COVID-19. However, the most commonly used nucleic acid detection method, qPCR or RT-qPCR, takes several hours to complete and requires highly ...
Mingzhu Yuan +3 more
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A dual-plasmid CRISPR/Cas system for mycotoxin elimination in polykaryotic industrial fungi.
ACS Synthetic Biology, 2020Mycotoxin contamination causes disease and death in both humans and animals. Monascus Red, produced by Monascus purpureus, is used as a food colorant.
Weiwei Liu +10 more
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Application of CRISPR-Cas systems in neuroscience
2021CRISPR-Cas systems have, over the years, emerged as indispensable tools for Genetic interrogation in contexts of clinical interventions, elucidation of genetic pathways and metabolic engineering and have pervaded almost every aspect of modern biology.
Deepro, Bonnerjee, Sangram, Bagh
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2013
Discovery and seminal developments in the CRISPR field.- Occurrence, diversity of CRISPR-Cas systems and genotyping implications.- Evolution and classification of CRISPR-Cas systems and Cas protein families.- Regulation of CRISPR-based immune responses.- crRNA Biogenesis.- Distribution and mechanism of the Type I CRISPR/Cas Systems.- Type II ...
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Discovery and seminal developments in the CRISPR field.- Occurrence, diversity of CRISPR-Cas systems and genotyping implications.- Evolution and classification of CRISPR-Cas systems and Cas protein families.- Regulation of CRISPR-based immune responses.- crRNA Biogenesis.- Distribution and mechanism of the Type I CRISPR/Cas Systems.- Type II ...
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Regulation of CRISPR–Cas adaptive immune systems
Current Opinion in Microbiology, 2017CRISPR-Cas systems are prokaryotic immune systems that allow defense against invasion by foreign genetic elements. Through the acquisition of genetic memory representing prior exposure, the CRISPR-Cas machinery identifies complementary nucleic acids and mediates their destruction.
Adrian G, Patterson +2 more
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