Results 131 to 140 of about 169 (164)
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An introduction and use of the CRISPR-Cas systems
2021Clusters of regularly interspaced short palindromic repeats (CRISPR) and CRISPR associated proteins (Cas) system (CRISPR-Cas) is a rapidly evolving field of targeted genome engineering. The type II CRISPR-Cas9 is used for genome editing of many organisms. Single guide RNA (sgRNA) can bind to Cas9 protein that can target desired sequences in presence of
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CRISPR-Cas systems in Serratia
2022The CRISPR-Cas system of Prokaryotes is an adaptive immune defense mechanism to protect themselves from invading genetic elements (e.g. phages and plasmids). Studies that describe the genetic organization of these prokaryotic systems have mainly reported on the Enterobacteriaceae family (now reorganized within the order Enterobacteriales).
Maria Scrascia +8 more
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CRISPR/Cas System: An Introduction
2021The process of altering genetic code to modify DNA precisely and efficiently within a cell is known as genome editing. All techniques used for changing a gene in a cell are based on cutting of double-stranded DNA through DNA endonucleases at specific site.
Nayla Munawar, Aftab Ahmad
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2013
Discovery and seminal developments in the CRISPR field.- Occurrence, diversity of CRISPR-Cas systems and genotyping implications.- Evolution and classification of CRISPR-Cas systems and Cas protein families.- Regulation of CRISPR-based immune responses.- crRNA Biogenesis.- Distribution and mechanism of the Type I CRISPR/Cas Systems.- Type II ...
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Discovery and seminal developments in the CRISPR field.- Occurrence, diversity of CRISPR-Cas systems and genotyping implications.- Evolution and classification of CRISPR-Cas systems and Cas protein families.- Regulation of CRISPR-based immune responses.- crRNA Biogenesis.- Distribution and mechanism of the Type I CRISPR/Cas Systems.- Type II ...
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The CRISPR-Cas system in molecular diagnostics
Clinica Chimica ActaRobust, sensitive, and rapid molecular detection tools are essential prerequisites for disease diagnosis and epidemiological control. However, the current mainstream tests necessitate expensive equipment and specialized operators, impeding the advancement of molecular diagnostics. The CRISPR-Cas system is an integral component of the bacterial adaptive
Rao, Song +3 more
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Advances in CRISPR-Cas systems for epigenetics
The CRISPR-Cas9 method has revolutionized the gene editing. Epigenetic changes, including DNA methylation, RNA modification, and changes in histone proteins, have been intensively studied and found to play a key role in the pathogenesis of human diseases.Mahnoor, Ilyas +6 more
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CRISPR‐Cas systems and RNA‐guided interference
WIREs RNA, 2013AbstractClustered regularly interspaced short palindromic repeats (CRISPR) together with associated sequences (cas) form the CRISPR‐Cas system, which provides adaptive immunity against viruses and plasmids in bacteria and archaea. Immunity is built through acquisition of short stretches of invasive nucleic acids into CRISPR loci as ‘spacers'.
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Alternative functions of CRISPR–Cas systems in the evolutionary arms race
Nature Reviews Microbiology, 2022Prarthana Mohanraju +2 more
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Structural biology of CRISPR–Cas immunity and genome editing enzymes
Nature Reviews Microbiology, 2022Joy Y Wang +2 more
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Delivery of CRISPR/Cas systems for cancer gene therapy and immunotherapy
Advanced Drug Delivery Reviews, 2021Xiangrong Song, Hai Huang, Siyan He
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