Results 141 to 150 of about 58,663 (324)
Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation
Advanced Science, EarlyView.At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao +14 more
wiley +1 more source
Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system [PDF]
, 2012 Kirill A. Datsenko +5 more
openalex +1 more source
Advanced Science, EarlyView.Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu +7 more
wiley +1 more source
Optimal number of spacers in CRISPR arrays
, 2017 We estimate the number of spacers in a CRISPR array of a bacterium which maximizes its protection against a viral attack. The optimality follows from a competition between two trends: too few distinct spacers make the bacteria vulnerable to an attack by ...
Ispolatov, Yaroslav +2 more
core +1 more source
Optimization of CRISPR-Cas systems in ectothermal organisms [PDF]
, 2020 CRISPR-Cas systems have been traditionally optimized for gene editing in different types of models, such as in mammalian cell lines. However, their implementation in animal models requires additional work. In addition, another impediment is the number of
Moreno Mateos, Miguel Ángel +1 more
core +1 more source
The CRISPR/Cas Adaptive Immune System of Pseudomonas aeruginosa Mediates Resistance to Naturally Occurring and Engineered Phages [PDF]
, 2012 Kyle C. Cady +4 more
openalex +1 more source
NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea
Advanced Science, EarlyView.This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi +16 more
wiley +1 more source
CRISPR RNA processing by a Type IV-A Cas6 endoribonuclease [PDF]
, 2018 The CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats - CRISPR ASsociated) system is an adaptive bacterial immune system. Upon infection by a foreign nucleic acid, such as phage, the bacterium\u27s CRISPR-Cas system takes a chunk of ...
Taylor, Hannah Nicole
core +1 more source
The Bacterial CRISPR/Cas System as Analog of the Mammalian Adaptive Immune System [PDF]
, 2012 Moran G. Goren +3 more
openalex +1 more source
AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells
Advanced Science, EarlyView.Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu +8 more
wiley +1 more source