Results 151 to 160 of about 713,183 (311)

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems [PDF]

, 2017
Microbial CRISPR-Cas systems are divided into Class 1, with multisubunit effector complexes, and Class 2, with single protein effectors. Currently, only two Class 2 effectors, Cas9 and Cpf1, are known.
Abudayyeh, Omar Osama, Gootenberg, Jonathan S, Joung, Julia, Konermann, Silvana M, Koonin, Eugene V., Makarova, Kira S., Minakhin, Leonid, Semenova, Ekaterina, Severinov, Konstantin, Shmakov, Sergey, Wolf, Yuri I., Zhang, Feng   +11 more
core   +1 more source

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

In silico comparative analysis of crispr-cas system structures of Yersinia pseudotuberculosis causing different clinical manifestations of pseudotuberculosis

Журнал инфектологии, 2019
The aim of this research was to analyze and compare CRIPSR loci and cas-proteins of Yersinia pseudotuberculosis strains isolated in different territories from patients with various clinical manifestations of pseudotuberculosis.Materials and Methods ...
N. P. Peretolchina, Yu. P. Dzhioev, A. Yu. Borisenko, L. A. Stepanenko, E. A. Voskresenskaya, V. T. Klimov, O. N. Reva, V. I. Zlobin   +7 more
doaj   +1 more source

Fractional Multidimensional System [PDF]

arXiv, 2017
The multidimensional ($n$-D) systems described by Roesser model are presented in this paper. These $n$-D systems consist of discrete systems and continuous fractional order systems with fractional order $\nu$, $0<\nu<1$. The stability and Robust stability of such $n$-D systems are investigated.
arxiv  

Programming native CRISPR arrays for the generation of targeted immunity [PDF]

, 2016
: The adaptive immune system of prokaryotes, called CRISPR-Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated genes), results in specific cleavage of invading nucleic acid sequences recognized by the cell’s “memory” of ...
Hynes, Alexander, Labrie, Simon, Moineau, Sylvain   +2 more
core   +2 more sources

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, EarlyView.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source

CircRNA‐mTOR Promotes Hepatocellular Carcinoma Progression and Lenvatinib Resistance Through the PSIP1/c‐Myc Axis

Advanced Science, EarlyView.
This study verifies that circRNA‐mTOR exhibits high expression levels in HCC and has a strong correlation with patient prognosis. Mechanistically, circRNA‐mTOR achieves this effect by facilitating the nuclear translocation of RNA‐binding protein (RBP) PSIP1 through specific binding.
Yongchang Tang, Feng Yuan, Mingbo Cao, Yupeng Ren, Yuxuan Li, Gaoyuan Yang, Zhaozhong Zhong, Hao Liang, Zhiyong Xiong, Zhiwei He, Nan Lin, Meihai Deng, Zhicheng Yao   +12 more
wiley   +1 more source

Exploiting CRISPR-Cas to manipulate Enterococcus faecalis populations

eLife, 2017
CRISPR-Cas provides a barrier to horizontal gene transfer in prokaryotes. It was previously observed that functional CRISPR-Cas systems are absent from multidrug-resistant (MDR) Enterococcus faecalis, which only possess an orphan CRISPR locus, termed ...
Karthik Hullahalli, Marinelle Rodrigues, Kelli L Palmer   +2 more
doaj   +1 more source

Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD‐MASH Transition by Disrupting Carnitine Biosynthesis

Advanced Science, EarlyView.
Takeda G protein‐coupled receptor 5 (TGR5) serves as a central regulator in the metabolic dysfunction‐associated steatotic liver disease (MASLD)/metabolic dysfunction‐associated steatohepatitis (MASH) transition via conjugated lithocholic acid (LCA). Mechanistically, TGR5 orchestrates lipotoxicity‐induced cell death through its interaction with CD36 ...
Senlin Lian, Meixi Lu, Luo Jiajing, Bin Zhang, Yi Fang, Xuran Wang, Minghua Zheng, Yan Ni, Guifang Xu, Yonglin Yang, Runqiu Jiang   +10 more
wiley   +1 more source

Cubical token systems [PDF]

arXiv, 2006
The paper deals with combinatorial and stochastic structures of cubical token systems. A cubical token system is an instance of a token system, which in turn is an instance of a transition system. It is shown that some basic results of combinatorial and stochastic parts of media theory hold almost in identical form for cubical token systems, although ...
arxiv